Perturbed T cell IL-7 receptor signaling in chronic Chagas disease

dc.creatorAlbareda, María Cecilia
dc.creatorPérez-Mazliah, Damián E
dc.creatorNatale, M Ailén
dc.creatorCastro Eiro, Melisa D
dc.creatorAlvarez, María G
dc.creatorViotti, Rodolfo
dc.creatorBertocchi, Graciela
dc.creatorLococo, Bruno
dc.creatorTarleton, Rick L
dc.creatorLaucella, Susana A.
dc.date2019-12-05T20:21:55Z
dc.date2019-12-05T20:21:55Z
dc.date2015-04-15
dc.date.accessioned2023-08-29T20:06:29Z
dc.date.available2023-08-29T20:06:29Z
dc.identifier1550-6606
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1463
dc.identifier10.4049/jimmunol.1402202
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519174
dc.descriptionFil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Natale, M. Ailén. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Alvarez, María G. Hospital Interzonal General de Agudos Eva Perón; Argentina.
dc.descriptionFil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón; Argentina.
dc.descriptionFil: Bertocchi, Graciela. Hospital Interzonal General de Agudos Eva Perón; Argentina.
dc.descriptionFil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón; Argentina.
dc.descriptionFil: Tarleton, Rick L. enter for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos.
dc.descriptionFil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionWe have previously demonstrated that immune responses in subjects with chronic Trypanosoma cruzi infection display features common to other persistent infections with signs of T cell exhaustion. Alterations in cytokine receptor signal transduction have emerged as one of the cell-intrinsic mechanisms of T cell exhaustion. In this study, we performed an analysis of the expression of IL-7R components (CD127 and CD132) on CD4(+) and CD8(+) T cells and evaluated IL-7-dependent signaling events in patients at different clinical stages of chronic chagasic heart disease. Subjects with no signs of cardiac disease showed a decrease in CD127(+)CD132(+) cells and a reciprocal gain of CD127(-)CD132(+) in CD8(+) and CD4(+) T cells compared with either patients exhibiting heart enlargement or uninfected controls. T. cruzi infection, in vitro, was able to stimulate the downregulation of CD127 and the upregulation of CD132 on T cells. IL-7-induced phosphorylation of STAT5 as well as Bcl-2 and CD25 expression were lower in T. cruzi-infected subjects compared with uninfected controls. The serum levels of IL-7 were also increased in chronic chagasic patients. The present study highlights perturbed IL-7/IL-7R T cell signaling through STAT5 as a potential mechanism of T cell exhaustion in chronic T. cruzi infection.
dc.formatpdf
dc.languageen
dc.relationJournal of immunology (Baltimore, Md. : 1950)
dc.rightsopen
dc.sourceJournal of immunology (Baltimore, Md.:1950) 2015;194(8):3883-3889
dc.subjectTrypanosoma cruzi
dc.subjectReceptores de Citocinas
dc.subjectEnfermedad de Chagas
dc.titlePerturbed T cell IL-7 receptor signaling in chronic Chagas disease
dc.typeArtículo


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