dc.creatorBustos, Patricia L.
dc.creatorVolta, Bibiana J.
dc.creatorPerrone, Alina E.
dc.creatorMilduberger, Natalia
dc.creatorBua, Jacqueline
dc.date2019-12-04T19:39:10Z
dc.date2019-12-04T19:39:10Z
dc.date2017
dc.date.accessioned2023-08-29T20:06:24Z
dc.date.available2023-08-29T20:06:24Z
dc.identifier2058-7716
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1437
dc.identifier10.1038/cddiscovery.2016.92
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519132
dc.descriptionFil: Bustos, Patricia L. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina.
dc.descriptionFil: Volta, Bibiana J. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina.
dc.descriptionFil: Perrone, Alina E. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina.
dc.descriptionFil: Milduberger, Natalia. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina.
dc.descriptionFil: Bua, Jacqueline. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentina.
dc.descriptionMitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, modulated by cyclophilin D (CyPD), a crucial component of this protein complex. In Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, we have previously described that mitochondrial permeability transition occurs after oxidative stress induction in a cyclosporin A-dependent manner, a well-known cyclophilin inhibitor. In the present work, a mitochondrial parasite cyclophilin, named TcCyP22, which is homolog to the mammalian CyPD was identified. TcCyP22-overexpressing parasites showed an enhanced loss of mitochondrial membrane potential and loss of cell viability when exposed to a hydrogen peroxide stimulus compared with control parasites. Our results describe for the first time in a protozoan parasite that a mitochondrial cyclophilin is a component of the permeability transition pore and is involved in regulated cell death induced by oxidative stress.
dc.languageen
dc.relationCell death discovery
dc.rightsopen
dc.subjectCiclofilina D
dc.subjectApoptosis
dc.subjectEstrés Oxidativo
dc.titleA homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress-damage response
dc.typeArtículo


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