Trypanosoma cruzi infection induces the expression of CD40 in murine cardiomyocytes favoring CD40 ligation-dependent production of cardiopathogenic IL-6

dc.creatorAyala, Mariela Alejandra Moreno
dc.creatorCasasco, Agustina
dc.creatorGonzalez, Mariela N.
dc.creatorPostan, Miriam
dc.creatorCorral, Ricardo Santiago
dc.creatorPetray, Patricia Beatriz
dc.date2019-12-04T18:50:29Z
dc.date2019-12-04T18:50:29Z
dc.date2016-02
dc.date.accessioned2023-08-29T20:06:22Z
dc.date.available2023-08-29T20:06:22Z
dc.identifier1432-1955
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1427
dc.identifier10.1007/s00436-015-4805-4
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519114
dc.descriptionFil: Ayala, Mariela Alejandra Moreno. Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños Ricardo Gutiérrez, Gallo 1330, Buenos Aires; Argentina.
dc.descriptionFil: Casasco, Agustina. Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños Ricardo Gutiérrez, Gallo 1330, Buenos Aires; Argentina.
dc.descriptionFil: Gonzalez, Mariela N. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Corral, Ricardo Santiago. Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños Ricardo Gutiérrez, Gallo 1330, Buenos Aires; Argentina.
dc.descriptionFil: Petray, Patricia Beatriz. Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños Ricardo Gutiérrez, Gallo 1330, Buenos Aires; Argentina.
dc.descriptionThe inflammatory response in the myocardium is an important aspect of the pathogenesis of Chagas' heart disease raised by Trypanosoma cruzi. CD40, a transmembrane type I receptor belonging to the tumor necrosis factor receptor (TNFR) family, is expressed in a broad spectrum of cell types and is crucial in several inflammatory and autoimmune diseases. Activation of CD40 through ligation to CD40L (CD154) induces multiple effects, including the secretion of proinflammatory molecules. In the present study, we examined the ability of T. cruzi to trigger the expression of CD40 in cardiac myocytes in vitro and in a murine model of chagasic cardiomyopathy. Our results indicate, for the first time, that T. cruzi is able to induce the expression of CD40 in HL-1 murine cardiomyocytes. Moreover, ligation of CD40 receptor upregulated interleukin-6 (IL-6), associated with inflammation. Furthermore, the induction of this costimulatory molecule was demonstrated in vivo in myocardium of mice infected with T. cruzi. This suggests that CD40-bearing cardiac muscle cells could interact with CD40L-expressing lymphocytes infiltrating the heart, thus contributing to inflammatory injury in chagasic cardiomyopathy.
dc.languageen
dc.relationParasitology research
dc.rightsnone
dc.sourceParasitology Research 2016; 115(2):779-85.
dc.subjectAntígenos CD40
dc.subjectMiocitos Cardíacos
dc.subjectEnfermedad de Chagas
dc.subjectTrypanosoma cruzi
dc.titleTrypanosoma cruzi infection induces the expression of CD40 in murine cardiomyocytes favoring CD40 ligation-dependent production of cardiopathogenic IL-6
dc.typeArtículo


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