Assessment of CD8(+) T cell differentiation in Trypanosoma cruzi-infected children

dc.creatorAlbareda, María Cecilia
dc.creatorOlivera, Gabriela C
dc.creatorDe Rissio, Ana María
dc.creatorPostan, Miriam
dc.date2013-07-24T01:32:31Z
dc.date2013-07-24T01:32:31Z
dc.date2010
dc.date.accessioned2023-08-29T20:04:17Z
dc.date.available2023-08-29T20:04:17Z
dc.identifier1476-1645
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/531
dc.identifierhttps://doi.org/10.4269/ajtmh.2010.09-0604
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8517916
dc.descriptionFil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Olivera, Gabriela C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionWe previously reported that the T cell compartment in chronically Trypanosoma cruzi-infected adult subjects display functional and phenotypic signs of immune senescence. This study aimed to investigate the differentiation and the senescent profile of the overall CD8(+) T cell compartment in T. cruzi-infected children at the early stage of the disease. We found a lower percentage of naive (CD27(+)CD28(+)CD45RA(+)) and early antigen-experienced (CD45RA(-)CD27(+)CD28(+)), and higher percentages of late differentiated antigen-experienced (CD45RA(-)CD27(-)CD28(-)) CD8(+) T cells in T. cruzi-infected children as compared with age-matched uninfected controls. The expression of the interleukin (IL)-7R is also decreased on naive and on antigen-experienced total CD8(+) T cells with various degrees of differentiation. Conversely, the expression of HLA-DR, caspase-3, and CD57 did not vary on the total CD8(+) T cell compartment. These findings suggest that the duration of the infection is relevant in the process of immune senescent that this parasite can induce.
dc.formatpdf
dc.languageen
dc.relationThe American journal of tropical medicine and hygiene
dc.rightsopen
dc.sourceThe American journal of tropical medicine and hygiene, 2010, 82(5), 861-864.
dc.subjectEnfermedad de Chagas
dc.subjectLinfocitos T CD8-positivos
dc.subjectDiferenciación Celular
dc.subjectCitocinas
dc.subjectRegulación de la Expresión Génica
dc.titleAssessment of CD8(+) T cell differentiation in Trypanosoma cruzi-infected children
dc.typeArtículo


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