dc.creator | Ciapponi, Agustin | |
dc.creator | Bardach, Ariel | |
dc.creator | Glujovsky, Demian | |
dc.creator | Gibbons, Luz | |
dc.creator | Picconi, María Alejandra | |
dc.date | 2012-11-23T16:07:22Z | |
dc.date | 2012-11-23T16:07:22Z | |
dc.date | 2011 | |
dc.date.accessioned | 2023-08-29T20:03:51Z | |
dc.date.available | 2023-08-29T20:03:51Z | |
dc.identifier | 1932-6203 | |
dc.identifier | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025493 | |
dc.identifier | http://sgc.anlis.gob.ar/handle/123456789/398 | |
dc.identifier | 10.1371/journal.pone.0025493. | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8517719 | |
dc.description | Fil: Ciapponi, Agustin. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. | |
dc.description | Fil: Bardach, Ariel. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. | |
dc.description | Fil: Glujovsky, Demian. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. | |
dc.description | Fil: Gibbons, Luz. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. | |
dc.description | Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio Virus Oncogénicos; Argentina. | |
dc.description | Background: Cervical cancer is a major public health problem in Latin America and the Caribbean (LA&C), showing some of the highest incidence and mortality rates worldwide. Information on HPV type distribution in high-grade cervical lesions (HSIL) and invasive cervical cancer (ICC) is crucial to predict the future impact of HPV16/18 vaccines and screening programmes, and to establish an appropriate post-vaccinal virologic surveillance. The aim was to assess the prevalence of HPV types in HSIL and ICC in studies in LA&C. Methods and Findings: We performed a systematic review, following the MOOSE guidelines for systematic reviews of observational studies, and the PRISMA statement for reporting systematic reviews and meta-analyses. Inclusion criteria were at least ten cases of HSIL/ICC, and HPV-type elicitation. The search, without language restrictions, was performed in MEDLINE, Cochrane Library, EMBASE, LILACS from inception date to December 2009, proceedings, reference lists and consulting experts. A meta-analysis was performed using arc-sine transformations to stabilize the variance of simple proportions. Seventy-nine studies from 18 countries were identified, including 2446 cases of HSIL and 5540 of ICC. Overall, 46.5% of HSIL cases harbored HPV 16 and 8.9% HPV18; in ICC, 53.2% of cases harbored HPV 16 and 13.2% HPV 18. The next five most common types, in decreasing frequency, were HPV 31, 58, 33, 45, and 52. Study's limitations comprise the cross-sectional design of most included studies and their inherent risk of bias, the lack of representativeness, and variations in the HPV type-specific sensitivity of different PCR protocols. Conclusions: This study is the broadest summary of HPV type distribution in HSIL and ICC in LA&C to date. These data are essential for local decision makers regarding HPV screening and vaccination policies. Continued HPV surveillance would be useful, to assess the potential for changing type-specific HPV prevalence in the post-vaccination era in Latin America. | |
dc.format | application/pdf | |
dc.language | en | |
dc.publisher | Yes | |
dc.relation | Plos one | |
dc.rights | open | |
dc.source | PloS One 2011; 6(10): e25493. | |
dc.subject | Neoplasias | |
dc.subject | Neoplasias del Cuello Uterino | |
dc.subject | Infecciones por Papillomavirus | |
dc.subject | América Latina | |
dc.subject | Región del Caribe | |
dc.title | Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis | |
dc.type | Artículo | |
dc.coverage | América Latina | |
dc.coverage | Región del Caribe | |
dc.coverage | Región del Caribe | |