Molecular identification and characterization of two proposed new enterovirus serotypes, EV74 and EV75

dc.creatorOberste, M. Steven
dc.creatorMichele, Suzanne M.
dc.creatorMaher, Kaija
dc.creatorSchnurr, David
dc.creatorCisterna, Daniel
dc.creatorJunttila, Nina
dc.creatorUddin, Moyez
dc.creatorChomel, Jean-Jacques
dc.creatorLau, Chi-Shan
dc.creatorRidha, Walid
dc.creatorAl-Busaidy, Suleiman
dc.creatorNorder, Helene
dc.creatorMagnius, Lars O.
dc.creatorPallansch, Mark A.
dc.date2012-11-23T13:19:57Z
dc.date2012-11-23T13:19:57Z
dc.date2004
dc.date.accessioned2023-08-29T20:03:51Z
dc.date.available2023-08-29T20:03:51Z
dc.identifier0022-1317
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/396
dc.identifierhttp://vir.sgmjournals.org/content/85/11/3205.full.pdf
dc.identifier10.1099/vir.0.80148-0
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8517714
dc.descriptionFil: Oberste, M. Steven. Centers for Disease Control and Prevention. Respiratory and Enteric Viruses Branch; Estados Unidos.
dc.descriptionFil: Michele, Suzanne M. Centers for Disease Control and Prevention. Respiratory and Enteric Viruses Branch; Estados Unidos.
dc.descriptionFil: Maher, Kaija. Centers for Disease Control and Prevention. Respiratory and Enteric Viruses Branch; Estados Unidos.
dc.descriptionFil: Schnurr, David. California Department of Health Services. Viral and Rickettsial Disease Laboratory; Estados Unidos.
dc.descriptionFil: Cisterna, Daniel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Junttila, Nina. Swedish Institute for Disease Control. Department of Virology; Suecia.
dc.descriptionFil: Uddin, Moyez. Institute of Public Health; Bangladesh.
dc.descriptionFil: Chomel, Jean-Jacques. Centre National de Référence des Entérovirus; Francia.
dc.descriptionFil: Lau, Chi-Shan. Queen Mary Hospital. Department of Health; China.
dc.descriptionFil: Ridha, Walid. National Polio Laboratory; Irak.
dc.descriptionFil: Al-Busaidy, Suleiman. Ministry of Health. Department of Laboratories; Oman.
dc.descriptionFil: Norder, Helene. Swedish Institute for Disease Control. Department of Virology; Suecia.
dc.descriptionFil: Magnius, Lars O. Swedish Institute for Disease Control. Department of Virology; Suecia.
dc.descriptionFil: Pallansch, Mark A. Centers for Disease Control and Prevention. Respiratory and Enteric Viruses Branch; Estados Unidos.
dc.descriptionSequencing of the gene that encodes the capsid protein VP1 has been used as a surrogate for antigenic typing in order to distinguish enterovirus serotypes; three new serotypes were identified recently by this method. In this study, 14 enterovirus isolates from six countries were characterized as members of two new types within the species Human enterovirus B, based on sequencing of the complete capsid-encoding (P1) region. Isolates within each of these two types differed significantly from one another and from all other known enterovirus serotypes on the basis of sequences that encode either VP1 alone or the entire P1 region. Members of each type were greater than or equal to 77(.)2% identical to one another (89(.)5% amino acid identity) in VP1, but members of the two different types differed from one another and from other enteroviruses by greater than or equal to 31% in nucleotide sequence (25% amino acid sequence difference), indicating that the two groups represent separate new candidate enterovirus types. The complete P1 sequences differed from those of all other enterovirus serotypes by greater than or equal to 31% (26% amino acid sequence difference), but were highly conserved within a serotype (< 8% amino acid sequence difference). Phylogenetic analyses demonstrated that isolates of the same serotype were monophyletic in both VP1 and the capsid as a whole, as shown previously for other enterovirus serotypes. This paper proposes that these 14 isolates should be classified as members of two new human enterovirus types, enteroviruses 74 and 75 (EV74 and EV75).
dc.formatpdf
dc.languageen
dc.relationThe Journal of general virology
dc.rightsopen
dc.sourceJournal of General Virology 2004;85(11):3205-3212
dc.subjectEnterovirus
dc.subjectEnterovirus Humano B
dc.subjectPicornaviridae
dc.titleMolecular identification and characterization of two proposed new enterovirus serotypes, EV74 and EV75
dc.typeArtículo


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