Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970

dc.creatorLewis, Adrian P.
dc.creatorBok, Karin
dc.creatorPerez, O.
dc.creatorDeFillippo, J.
dc.creatorPaolazzi, C.
dc.creatorGomez, Jorge A.
dc.date2012-11-22T05:19:44Z
dc.date2012-11-22T05:19:44Z
dc.date2005
dc.date.accessioned2023-08-29T20:03:48Z
dc.date.available2023-08-29T20:03:48Z
dc.identifier1432-8798
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/384
dc.identifierhttp://link.springer.com/article/10.1007%2Fs00705-005-0498-9
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8517694
dc.descriptionFil: Lewis, Adrian P. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
dc.descriptionFil: Bok, Karin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
dc.descriptionFil: Perez, O. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
dc.descriptionFil: DeFillippo, J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
dc.descriptionFil: Paolazzi, C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
dc.descriptionFil: Gomez, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
dc.descriptionDue to recent political developments, smallpox has re-emerged as a serious threat. We recovered and characterized an old batch of smallpox vaccine, Malbrán strain, produced between 1945 and 1949. The virus was re-isolated and characterized by sequence analysis and biological activity in animals. Phylogenetic analysis using the hemagglutinin and A45R genes showed that the Malbrán strain was closely related to the Lister strain of vaccinia virus. In animals, the Malbrán strain exhibited low pathogenicity, confirming historical records. Mice immunized with the Malbrán strain survived a lethal challenge with cowpox virus. Thus, this strain of vaccinia virus remains a viable candidate as a smallpox vaccine.
dc.formatapplication/pdf
dc.languageen
dc.relationArchives of virology
dc.rightsopen
dc.sourceArchives of Virology, 2005, 150(7), 1485-1491.
dc.subjectArgentina
dc.subjectVacuna contra Viruela
dc.subjectVirus Vaccinia
dc.subjectVacunas Atenuadas
dc.subjectProteínas del Envoltorio Viral
dc.titleCharacterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970
dc.typeArtículo
dc.coverageARG
dc.coverage1937-1970


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