Hantavirus pulmonary syndrome in northwestern Argentina : circulation of Laguna Negra virus associated with Calomys callosus

dc.creatorLevis, Silvana
dc.creatorGarcia, Jorge
dc.creatorPini, Noemí
dc.creatorCalderón, Gladys
dc.creatorRamírez, Josefina
dc.creatorBravo, Daniel
dc.creatorSt. Jeor, Stephen
dc.creatorRipoll, Carlos
dc.creatorBego, Mariana
dc.creatorLozano, Elena
dc.creatorBarquez, Rubén
dc.creatorKsiazek, Thomas G.
dc.creatorEnria, Delia
dc.date2012-10-20T21:42:31Z
dc.date2012-10-20T21:42:31Z
dc.date2004
dc.date.accessioned2023-08-29T20:03:18Z
dc.date.available2023-08-29T20:03:18Z
dc.identifier1476-1645
dc.identifierhttp://www.ajtmh.org/content/71/5/658.full.pdf+html
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/242
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8517454
dc.descriptionThe purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses.
dc.descriptionFil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina.
dc.descriptionFil: Garcia, Jorge. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina.
dc.descriptionFil: Pini, Noemí. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina.
dc.descriptionFil: Calderón, Gladys. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina.
dc.descriptionFil: Ramírez, Josefina. Hospital San Miguel; Argentina.
dc.descriptionFil: Bravo, Daniel. Hospital Oscar Orías; Argentina.
dc.descriptionFil: St. Jeor, Stephen. University of Nevada. Department of Microbiology; Estados Unidos.
dc.descriptionFil: Ripoll, Carlos. Dirección de Epidemiología. San Salvador de Jujuy, Jujuy; Argentina.
dc.descriptionFil: Bego, Mariana. University of Nevada. Department of Microbiology; Estados Unidos.
dc.descriptionFil: Lozano, Elena. Hospital San Miguel; Argentina.
dc.descriptionFil: Barquez, Rubén. Fundación Miguel Lillo; Argentina.
dc.descriptionFil: Ksiazek, Thomas G. Centers for Disease Control and Prevention. Special Pathogens Branch; Estados Unidos.
dc.descriptionFil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui; Argentina.
dc.formatapplication/pdf
dc.languageen
dc.rightsopen
dc.sourceThe American Journal of Tropical Medicine and Hygiene, 2004, 71(5), 658–663.
dc.subjectHantavirus
dc.subjectSíndrome Pulmonar por Hantavirus
dc.subjectFilogenia
dc.subjectRatas
dc.subjectReacción en Cadena de la Polimerasa de Transcriptasa Inversa
dc.subjectARN Viral
dc.subjectRoedores
dc.subjectHumanos
dc.subjectArgentina
dc.titleHantavirus pulmonary syndrome in northwestern Argentina : circulation of Laguna Negra virus associated with Calomys callosus
dc.typeArtículo
dc.coverageARG


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