The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model

A atividade da azitromicina contra a Leishmania (Viannia) braziliensise a Leishmania (Leishmania) amazonensis no modelogolden hamster

dc.creatorSinagra, Angel
dc.creatorLuna, María Concepción
dc.creatorAbraham, David
dc.creatorRiarte, Adelina
dc.creatorKrolewiecki, Alejandro J.
dc.creatorIannella, María del Carmen
dc.date2012-10-19T13:45:15Z
dc.date2012-10-19T13:45:15Z
dc.date2007
dc.date.accessioned2023-08-29T20:03:16Z
dc.date.available2023-08-29T20:03:16Z
dc.identifier0037-8682
dc.identifierhttp://www.scielo.br/pdf/rsbmt/v40n6/a05v40n6.pdf
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/232
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8517434
dc.descriptionFil: Sinagra, Angel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Luna, Concepción. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology; Estados Unidos.
dc.descriptionFil: Riarte, Adelina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
dc.descriptionFil: Iannella, María del Carmen. Universidad de Buenos Aires. Departamento de Matemática; Argentina.
dc.descriptionFil: Krolewiecki, Alejandro J. Fundación Huésped. Área de Investigaciones Clínicas; Argentina.
dc.descriptionNew therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania(Leishmania) major has been previously demonstrated. Different responses among species of Leishmaniamake species-specific drug screening necessary. The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensiswas evaluated in golden hamsters infected through footpad injections of metacyclic promastigotes, and compared with untreated controls and animals treated with meglumine antimoniate. Footpad thickness, lesion cultures and dissemination sites were analyzed. Treatment of golden hamsters with oral azithromycin at 450mg/kg had no activity against infections with Leishmania (Leishmania) amazonensis. For infections due to Leishmania (Viannia) braziliensis, azithromycin demonstrated significant activity relative to untreated controls, but inferior to meglumine antimoniate, for controlling lesion size. Neither drug was able to totally eliminate parasites from the lesions. It was concluded that azithromycin has activity against Leishmania (Viannia) braziliensisbut not against Leishmania (Leishmania) amazonensisin this model.
dc.formatapplication/pdf
dc.languageen
dc.rightsopen
dc.sourceRevista da Sociedade Brasileira de Medicina Tropical 2007; 40(6): 627–630
dc.subjectLeishmania braziliensis
dc.subjectLeishmania
dc.subjectMesocricetus
dc.subjectAzitromicina
dc.titleThe activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
dc.titleA atividade da azitromicina contra a Leishmania (Viannia) braziliensise a Leishmania (Leishmania) amazonensis no modelogolden hamster
dc.typeArtículo


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