Atypical forms of Cryptococcus neoformans in CSF of an AIDS patient

dc.creatorBava, Javier
dc.creatorSolari, Ruben
dc.creatorIsla, Guillermina
dc.creatorTroncoso, Alcides
dc.date2012-10-18T23:31:29Z
dc.date2012-10-18T23:31:29Z
dc.date2008
dc.date.accessioned2023-08-29T20:03:14Z
dc.date.available2023-08-29T20:03:14Z
dc.identifier1972-2680
dc.identifierhttp://www.jidc.org/index.php/journal/article/view/19745513/116
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/227
dc.identifierhttps://doi.org/10.3855/jidc.207
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8517427
dc.descriptionFil: Bava, Javier. Universidad de La Plata. Micología; Argentina.
dc.descriptionFil: Solari, Ruben. Hospital de Enfermedades Infecciosas Francisco J. Muñiz; Argentina.
dc.descriptionFil: Isla, Guillermina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
dc.descriptionFil: Troncoso, Alcides. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Microbiología y Parasitología y Enfermedades Infecciosas; Argentina.
dc.descriptionThe microscopic recognition of typical rounded capsulated yeasts in centrifuged cerebrospinal fluid (CSF), stained with India ink, is a common, rapid and effective method for the diagnosis of cryptococcal meningitis among AIDS patients. The presence of atypical forms of Cryptococcus neoformans var. neoformans in samples of CSF of an AIDS patient with cryptococcosis treated at the University Hospital of Infectious Disease is presented. The India ink microscopy of three consecutive CSF samples revealed capsulated yeast with India ink particles in the deteriorated capsules and capsulated pseudohyophae. Clinically, the patient showed a subacute meningoencephalitis, with a clinical picture not particularly different from those commonly observed in patients with AIDS-associated cryptococcosis treated in our hospital. In all cases, the culture of the CSF showed colonies of C. neoformans with typical macro and micromorphology, and the in vitro susceptibility tests to amphotericin B, fluocitosine, itraconazole and fluconazole showed MIC values into the limits of sensitivity. The presence of atypical forms of C. neoformans, considered as an atypical finding, could be the consequence of an adaptive phenomenon of this fungal species to an impaired immunological status present in the host.
dc.formatapplication/pdf
dc.languageen
dc.relationJournal of Infection in Developing Countries
dc.rightsopen
dc.sourceJournal of Infection in Developing Countries, 2008, 2(5), 403–405.
dc.subjectCryptococcus neoformans
dc.subjectMeningitis Criptocócica
dc.subjectMeningoencefalitis
dc.subjectSíndrome de Inmunodeficiencia Adquirida
dc.subjectMicroscopía
dc.titleAtypical forms of Cryptococcus neoformans in CSF of an AIDS patient
dc.typeArtículo


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