Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorToyama, M. H.
dc.creatorToyama, D. O.
dc.creatorTorres, V. M.
dc.creatorPontes, G. C.
dc.creatorFarias, W. R. L.
dc.creatorMelo, F. R.
dc.creatorOliveira, S. C. B.
dc.creatorFagundes, F. H. R.
dc.creatorDiz Filho, E. B. S.
dc.creatorCavada, B. S.
dc.date2014-05-20T13:12:21Z
dc.date2016-10-25T16:32:49Z
dc.date2014-05-20T13:12:21Z
dc.date2016-10-25T16:32:49Z
dc.date2010-11-01
dc.date.accessioned2017-04-05T19:17:00Z
dc.date.available2017-04-05T19:17:00Z
dc.identifierProtein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010.
dc.identifier1572-3887
dc.identifierhttp://hdl.handle.net/11449/336
dc.identifierhttp://acervodigital.unesp.br/handle/11449/336
dc.identifier10.1007/s10930-010-9294-9
dc.identifierWOS:000284644400005
dc.identifierhttp://dx.doi.org/10.1007/s10930-010-9294-9
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/850667
dc.descriptionLow molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherSpringer
dc.relationProtein Journal
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBotryocladia occidentalis
dc.subjectCrotalus durissus cascavella
dc.subjectSecretory phospholipase A2 (sPLA2)
dc.subjectEdema
dc.subjectMyonecrosis
dc.titleEffects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
dc.typeOtro


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