Characterization of Atrazine-Loaded Biodegradable Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Microspheres

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGrillo, Renato
dc.creatorMelo, Nathalie F. S. de
dc.creatorLima, Renata de
dc.creatorLourenço, Roberto Wagner
dc.creatorRosa, Andre Henrique
dc.creatorFraceto, Leonardo Fernandes
dc.date2014-05-20T13:12:11Z
dc.date2016-10-25T16:32:32Z
dc.date2014-05-20T13:12:11Z
dc.date2016-10-25T16:32:32Z
dc.date2010-03-01
dc.date.accessioned2017-04-05T19:15:58Z
dc.date.available2017-04-05T19:15:58Z
dc.identifierJournal of Polymers and The Environment. New York: Springer/plenum Publishers, v. 18, n. 1, p. 26-32, 2010.
dc.identifier1566-2543
dc.identifierhttp://hdl.handle.net/11449/170
dc.identifierhttp://acervodigital.unesp.br/handle/11449/170
dc.identifier10.1007/s10924-009-0153-8
dc.identifierWOS:000278836800003
dc.identifier0000-0002-2042-018X
dc.identifierhttp://dx.doi.org/10.1007/s10924-009-0153-8
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/850538
dc.descriptionPolyhydroxybutyrate-co-hydroxyvalerate microspheres (PHBV-MS) were prepared as a delivery system for the herbicide atrazine (ATZ). Characterization of the system included investigation of in vitro release properties and genotoxicity. ATZ - PHBV-MS particle diameters showed a size distribution range of 1-13 mu m. Differential scanning calorimetry analyses indicated that ATZ was associated with the PHBV microparticles. The release profiles showed a different release behavior for the pure herbicide in solution, as compared with that containing ATZ-loaded PHBV-MS. Korsmeyer-Peppas model analyses showed that atrazine release from the microparticles occurred by a combination of diffusion through the matrix and partial diffusion through water-filled pores of the PHBV microparticles. A Lactuca sativa test result showed that the genotoxicity of ATZ-loaded PHBV-MP was decreased in relation to ATZ alone. The results demonstrate a viable biodegradable herbicide release system using atrazine for agrochemical purposes.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherSpringer/plenum Publishers
dc.relationJournal of Polymers and the Environment
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtrazine
dc.subjectPesticide
dc.subjectPHBV
dc.subjectMicrospheres
dc.subjectRelease system
dc.titleCharacterization of Atrazine-Loaded Biodegradable Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Microspheres
dc.typeOtro


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