| dc.creator | Galeano Jaramillo, Elkin de Jesús | |
| dc.creator | Thomas, Oliver P. | |
| dc.creator | Robledo Restrepo, Sara María | |
| dc.creator | Muñoz Herrera, Diana Lorena | |
| dc.creator | Martínez Martínez, Alejandro | |
| dc.date | 2020-01-11T21:30:03Z | |
| dc.date | 2020-01-11T21:30:03Z | |
| dc.date | 2011 | |
| dc.date.accessioned | 2023-08-28T21:01:41Z | |
| dc.date.available | 2023-08-28T21:01:41Z | |
| dc.identifier | Galeano Jaramillo, E. de J., Thomas, O. P., Robledo Restrepo, S. M., Muñoz Herrera, D. L., & Martínez Martínez, A. (2011). Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida. Marine Drugs, 9(10), 1902-1913. https://doi.org/10.3390/md9101902 | |
| dc.identifier | 1660-3397 | |
| dc.identifier | http://hdl.handle.net/10495/13067 | |
| dc.identifier | 10.3390/md9101902 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8487555 | |
| dc.description | ABSTARCT: Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determination of the isolated compounds was performed using one- and two-dimensional NMR, MS and other spectroscopy data. All isolated compounds were screened for their in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compounds 7 and 8 showed selective antiparasitic activity at 10 and 5 μM against Leishmania and Plasmodium parasites, respectively. Cytotoxicity of these compounds on a human promonocytic cell line was also assessed. | |
| dc.format | 11 | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | MDPI | |
| dc.publisher | Productos Naturales Marinos | |
| dc.publisher | Programa de Estudio y Control de Enfermedades Tropicales (PECET) | |
| dc.publisher | Suiza | |
| dc.relation | Mar. Drugs | |
| dc.rights | Atribución 2.5 Colombia (CC BY 2.5 CO) | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | https://creativecommons.org/licenses/by/2.5/co/ | |
| dc.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Antiparasitarios | |
| dc.subject | Agentes antiparasitarios | |
| dc.subject | Antiparasitic agents | |
| dc.subject | Esponjas | |
| dc.subject | sponges | |
| dc.subject | Bromotirosina | |
| dc.subject | Esponja marina Verongula rigida | |
| dc.subject | http://aims.fao.org/aos/agrovoc/c_7321 | |
| dc.title | Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.type | https://purl.org/redcol/resource_type/ART | |
| dc.type | Artículo de investigación | |
