Phenotypical characterization of regulatory T cells in humans and rodents

dc.creatorRodríguez Perea, Ana Lucía
dc.creatorArcia Anaya, Eliuth David
dc.creatorRueda Ríos, César Mauricio
dc.creatorVelilla Hernández, Paula Andrea
dc.date2022-11-21T14:05:22Z
dc.date2022-11-21T14:05:22Z
dc.date2016
dc.date.accessioned2023-08-28T20:46:47Z
dc.date.available2023-08-28T20:46:47Z
dc.identifierRodríguez-Perea AL, Arcia ED, Rueda CM, Velilla PA. Phenotypical characterization of regulatory T cells in humans and rodents. Clin Exp Immunol. 2016 Sep;185(3):281-91. doi: 10.1111/cei.12804.
dc.identifier0009-9104
dc.identifierhttps://hdl.handle.net/10495/32161
dc.identifier10.1111/cei.12804
dc.identifier1365-2249
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8484149
dc.descriptionABSTRACT: Regulatory T cells (Tregs) constitute a fascinating subpopulation of CD4 (+) T cells due to their ability to limit the immune response against self and non-self-antigens. Murine models and antibodies directed against surface and intracellular molecules have allowed elucidation of the mechanisms that govern their development and function. However, these markers used to their classification lack of specificity, as they can be expressed by activated T cells. Similarly, there are slight differences between animal models, in steady state and pathological conditions, anatomical localization and strategy of analysis by flow cytometry. Here, we revised the most common markers utilized for Treg typification by flow cytometry such as CD25, forkhead box protein 3 (FoxP3) and CD127, along with our data obtained in different body compartments of humans, mice and rats. Furthermore, we revised and determined the expression of other molecules important for the phenotypical characterization of Treg cells. We draw attention to the drawbacks of those markers used in chronic states of inflammation. However, until a specific marker for the identification of Tregs is discovered, the best combination of markers will depend upon the tissue or the degree of inflammation from which Tregs derive.
dc.descriptionCOL0012444
dc.format11
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherBritish Society for Immunology
dc.publisherInmunovirología
dc.publisherOxford, Inglaterra
dc.relationClin Exp Immunol
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiomarcadores
dc.subjectBiomarkers
dc.subjectGanglios Linfáticos
dc.subjectLymph Nodes
dc.subjectActivación de Linfocitos
dc.subjectLymphocyte Activation
dc.subjectLinfocitos T Reguladores
dc.subjectT-Lymphocytes, Regulatory
dc.subjectBazo
dc.subjectSpleen
dc.subjectRatas
dc.subjectRats
dc.subjectCD4 Antigens
dc.subjectCD4 Antigens
dc.subjectFactores de Transcripción Forkhead
dc.subjectForkhead Transcription Factors
dc.titlePhenotypical characterization of regulatory T cells in humans and rodents
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_dcae04bc
dc.typehttps://purl.org/redcol/resource_type/ARTREV
dc.typeArtículo de revisión


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