Evaluating the X Chromosome-Specific Diversity of Colombian Populations Using Insertion/Deletion Polymorphisms

dc.creatorIbarra Rodríguez, Adriana Alexandra
dc.creatorRestrepo Arango, Tomás
dc.creatorRojas Montoya, Winston
dc.creatorCastillo Pico, Adriana
dc.creatorAmorim, António
dc.creatorMartínez Alfaro, Beatriz
dc.creatorBurgos Figueroa, German
dc.creatorOstos Alfonso, Henry
dc.creatorÁlvarez Díaz, Karen Dayanna
dc.creatorCamacho Ospina, Mauricio
dc.creatorSuárez Molina, Olga Zuleima
dc.creatorPereira, Rui
dc.creatorGusmaõ, Leonor
dc.date2021-12-14T13:31:08Z
dc.date2021-12-14T13:31:08Z
dc.date2014
dc.date.accessioned2023-08-28T20:46:32Z
dc.date.available2023-08-28T20:46:32Z
dc.identifierIbarra, A., Restrepo, T., Rojas, W., Castillo, A., Amorim, A., et al. (2014) Evaluating the X Chromosome-Specific Diversity of Colombian Populations Using Insertion/Deletion Polymorphisms. PLOS ONE 9(1): e87202. https://doi.org/10.1371/journal.pone.0087202
dc.identifierhttp://hdl.handle.net/10495/25044
dc.identifier10.1371/journal.pone.0087202
dc.identifier1932-6203
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8484090
dc.descriptionABSTRACT: The European and African contribution to the pre-existing Native American background has influenced the complex genetic pool of Colombia. Because colonisation was not homogeneous in this country, current populations are, therefore, expected to have different proportions of Native American, European and African ancestral contributions. The aim of this work was to examine 11 urban admixed populations and a Native American group, called Pastos, for 32 X chromosome indel markers to expand the current knowledge concerning the genetic background of Colombia. The results revealed a highly diverse genetic background comprising all admixed populations, harbouring important X chromosome contributions from all continental source populations. In addition, Colombia is genetically sub-structured, with different proportions of European and African influxes depending on the regions. The samples from the North Pacific and Caribbean coasts have a high African ancestry, showing the highest levels of diversity. The sample from the South Andean region showed the lowest diversity and significantly higher proportion of Native American ancestry than the other samples from the North Pacific and Caribbean coasts, Central-West and Central-East Andean regions, and the Orinoquian region. The results of admixture analysis using X-chromosomal markers suggest that the high proportion of African ancestry in the North Pacific coast was primarily male driven. These men have joined to females with higher Native American and European ancestry (likely resulting from a classic colonial asymmetric mating type: European male x Amerindian female). This high proportion of male-mediated African contributions is atypical of colonial settings, suggesting that the admixture occurred during a period when African people were no longer enslaved. In the remaining regions, the African contribution was primarily female-mediated, whereas the European counterpart was primarily male driven and the Native American ancestry contribution was not gender biased.
dc.descriptionCOL0035429
dc.descriptionCOL0006723
dc.format10
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.publisherGenética Molecular (GENMOL)
dc.publisherIdentificación Genética - IdentiGEN
dc.publisherSan Francisco, Estados Unidos
dc.relationPLoS ONE.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectColombia
dc.subjectGrupo de Ascendencia Continental Nativa Americana
dc.subjectAmerican Native Continental Ancestry Group
dc.subjectGenética de población humana
dc.subjectHuman population genetics
dc.subjectEuropa
dc.subjectCromosomas X
dc.subjectX chromosome
dc.subjectAfricanos
dc.subjectAfricans
dc.subjectAfroamericanos
dc.subjectAfro-americans
dc.titleEvaluating the X Chromosome-Specific Diversity of Colombian Populations Using Insertion/Deletion Polymorphisms
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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