Characterisation of virulence genes in methicillin susceptible and resistant Staphylococcus aureus isolates from a paediatric population in a university hospital of Medellín, Colombia

dc.creatorJiménez Quiceno, Judy Natalia
dc.creatorOcampo Ríos, Ana María
dc.creatorVanegas Múnera, Johanna Marcela
dc.creatorRodríguez Tamayo, Erika Andrea
dc.creatorGarcés Samudio, Carlos Guillermo
dc.creatorPatiño Polanco, Luz Adriana
dc.creatorOspina, Sigifredo
dc.creatorCorrea Ochoa, Margarita María
dc.date2022-04-25T13:38:37Z
dc.date2022-04-25T13:38:37Z
dc.date2011
dc.date.accessioned2023-08-28T20:44:17Z
dc.date.available2023-08-28T20:44:17Z
dc.identifierJiménez JN, Ocampo AM, Vanegas JM, Rodríguez EA, Garcés CG, Patiño LA, Ospina S, Correa MM. Characterisation of virulence genes in methicillin susceptible and resistant Staphylococcus aureus isolates from a paediatric population in a university hospital of Medellín, Colombia. Mem Inst Oswaldo Cruz. 2011 Dec;106(8):980-5. doi: 10.1590/s0074-02762011000800013.
dc.identifier0074-0276
dc.identifierhttp://hdl.handle.net/10495/27736
dc.identifier10.1590/S0074-02762011000800013
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8483563
dc.descriptionABSTRACT : Virulence and antibiotic resistance are significant determinants of the types of infections caused by Staphylococcus aureus and paediatric groups remain among the most commonly affected populations. The goal of this study was to characterise virulence genes of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) strains isolated from a paediatric population of a Colombian University Hospital during 2009. Sixty MSSA and MRSA isolates were obtained from paediatric patients between zero-14 years. We identified the genes encoding virulence factors, which included Panton-Valentine leucocidine (PVL), staphylococcal enterotoxins A-E, exfoliative toxins A and B and toxic shock syndrome toxin 1. Typing of the staphylococcal chromosome cassette mec (SCCmec) was performed in MRSA strains. The virulence genes were more diverse and frequent in MSSA than in MRSA isolates (83% vs. 73%). MRSA strains harboured SCCmec types IVc (60%), I (30%), IVa (7%) and V (3%). SCCmec type IVc isolates frequently carried the PVL encoding genes and harboured virulence determinants resembling susceptible strains while SCCmec type I isolates were often negative. PVL was not exclusive to skin and soft tissue infections. As previously suggested, these differences in the distribution of virulence factor genes may be due to the fitness cost associated with methicillin resistance.
dc.descriptionCOL0013746
dc.descriptionCOL0058784
dc.format6
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Oswaldo Cruz
dc.publisherGrupo de Investigación Clínica en Enfermedades del Niño y del Adolescente - Pediaciencias
dc.publisherMicrobiología Molecular
dc.publisherRío de Janeiro, Brasil
dc.relationMem. Inst. Oswaldo Cruz.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectStaphylococcus aureus
dc.subjectFactores de Virulencia
dc.subjectVirulence Factors
dc.subjectStaphylococcus aureus Resistente a Meticilina
dc.subjectMethicillin-Resistant Staphylococcus aureus
dc.titleCharacterisation of virulence genes in methicillin susceptible and resistant Staphylococcus aureus isolates from a paediatric population in a university hospital of Medellín, Colombia
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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