dc.creatorÖzcan, Ipek
dc.creatorBouchemal, Kawthar
dc.creatorSegura Sánchez, Freimar
dc.creatorAbacıa, Özlem
dc.creatorÖzer, Özgen
dc.creatorGüneri, Tamer
dc.creatorPonchel, Gilles
dc.date2021-11-13T15:50:37Z
dc.date2021-11-13T15:50:37Z
dc.date2009
dc.date.accessioned2023-08-28T20:40:16Z
dc.date.available2023-08-28T20:40:16Z
dc.identifier2636-8552
dc.identifierhttp://hdl.handle.net/10495/24058
dc.identifier1307-2080
dc.identifierhttps://www.actapharmsci.com/abstract.php?id=9
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8482622
dc.descriptionABSTRACT: Nanoparticles were prepared by nanoprecipitation technique using poly (1-benzyl-L-glutamate) (PBLG) derivatives. Injectable nanoparticles were assessed for their in vitro properties such as particle size, polydispersity index, zeta potential and surface properties. The possibilities of sterilizing PBLG nanoparticle suspensions by membrane fıltration or autoclaving were evaluated. It was found that among these techniques, sterilization with membrane filtration seemed to be the most appropriate technique with any significant effect on in vitro and surface properties. Sterility was assessed on üe final product according to pharmacopoeial requirements. Sterility testing results showed no microbial contamination indicating that sterile nanoparticle formulations have been achieved after membrane filtration.
dc.descriptionCOL0065152
dc.format8
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherİstanbul Medipol University
dc.publisherBIOPOLIMER
dc.publisherEstambul, Turquía
dc.relationActa Pharm. Sci.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSeparación por membrana
dc.subjectMembrane separation
dc.subjectEsterilidad
dc.subjectSterility
dc.subjectPoly (y-benzyl-L-glutamate)
dc.subjectPegylated nanoparticles
dc.titleEffects of sterilization techniques on the Pegylated poly (y-benzyl-L-glutamate) (PBLG) nanoparticles
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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