Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis

dc.creatorBarrera García, Anabel
dc.creatorGómez Puerta, José Alfredo
dc.creatorArias Restrepo, Luis Fernando
dc.creatorBurbano Arciniegas, Catalina
dc.creatorRestrepo Escobar, Mauricio
dc.creatorVanegas García, Adriana Lucía
dc.creatorMuñoz Vahos, Carlos Horacio
dc.creatorRojas López, Mauricio
dc.creatorGonzález Naranjo, Luis Alonso
dc.creatorVásquez Duque, Gloria María
dc.date2022-02-21T20:32:58Z
dc.date2022-02-21T20:32:58Z
dc.date2016
dc.date.accessioned2023-08-28T20:16:54Z
dc.date.available2023-08-28T20:16:54Z
dc.identifierBarrera García A, Gómez-Puerta JA, Arias LF, Burbano C, Restrepo M, Vanegas AL, et al. Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis. Cervera R, editor. Autoimmune Dis [Internet]. 2016;2016:9324315. Disponible en: https://doi.org/10.1155/2016/9324315
dc.identifier2090-0422
dc.identifierhttp://hdl.handle.net/10495/26138
dc.identifier10.1155/2016/9324315
dc.identifier2090-0430
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8476661
dc.descriptionABSTRACT: Our aim was to characterize glomerular monocytes (Mo) infiltration and to correlate them with peripheral circulating Mo subsets and severity of lupus nephritis (LN). Methods. We evaluated 48 LN biopsy samples from a referral hospital. Recognition of Mo cells was done using microscopic view and immunohistochemistry stain with CD14 and CD16. Based on the number of cells, we classified LN samples as low degree of diffuse infiltration (<5 cells) and high degree of diffuse infiltration (≥5 cells). Immunophenotyping of peripheral Mo subsets was done using flow cytometry. Results. Mean age was years and the mean SLEDAI was . The most common SLE manifestations were proteinuria (91%) and hypocomplementemia (75%). Severe LN was found in 70% of patients (Class III, 27%; Class IV, 43%). Severe LN patients and patients with higher grade of CD16+ infiltration had lower levels of nonclassical (CD14+CD16++) Mo in peripheral blood. Conclusions. Our results might suggest that those patients with more severe forms of LN had a higher grade of CD14+CD16+ infiltration and lower peripheral levels of nonclassical (CD14+CD16++) Mo and might reflect a recruitment process in renal tissues. However, given the small sample, our results must be interpreted carefully.
dc.descriptionCOL0008639
dc.descriptionCOL0010959
dc.format8
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi
dc.publisherGrupo de Inmunología Celular e Inmunogenética
dc.publisherGrupo de Reumatología Universidad de Antioquia -GRUA-
dc.publisherNueva York, Estados Unidos
dc.relationAutoimmune Dis.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectReceptores de IgG
dc.subjectReceptors, IgG
dc.subjectNefritis Lúpica
dc.subjectLupus Nephritis
dc.subjectReceptores de Lipopolisacáridos
dc.subjectLipopolysaccharide Receptors
dc.titleInfiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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