Immunological identification of Trypanosoma cruzi lineages in human infection along the endemic area

dc.creatorRisso, Marikena
dc.creatorSartor, Paula
dc.creatorBurgos, Juan
dc.creatorBriceño, Luis
dc.creatorRodríguez, Eva
dc.creatorGuhl, Felipe
dc.creatorTriana Chávez, Omar
dc.creatorEspinoza, Berta
dc.creatorMonteón Padilla, Víctor Manuel
dc.creatorRussomando, Graciela
dc.creatorSchijman, Alejandro
dc.creatorBottasso, Oscar
dc.creatorLeguizamon, María Susana
dc.date2022-03-22T17:05:42Z
dc.date2022-03-22T17:05:42Z
dc.date2011
dc.date.accessioned2023-08-28T20:14:44Z
dc.date.available2023-08-28T20:14:44Z
dc.identifierRisso, M., Sartor, P. A., Burgos, J., Briceño, L., Rodríguez, E., Guhl, F., Triana, O., Espinoza, B., Monteón, V., Russomando, G., Schijman, A., Bottasso, O., & Leguizamón, M. (2011). Immunological identification of Trypanosoma cruzi lineages in human infection along the endemic area. The American journal of tropical medicine and hygiene, 84(1), 78–84. https://doi.org/10.4269/ajtmh.2011.10-0177
dc.identifier0002-9637
dc.identifierhttp://hdl.handle.net/10495/26765
dc.identifier10.4269/ajtmh.2011.10-0177
dc.identifier1476-1645
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8476082
dc.descriptionABSTRACT: Genotyping studies show a polarized geographic distribution of Trypanosoma cruzi lineages in humans. Here, we assessed their distribution along Latin America through an immunological approach we designated Western blot (WB) assay with Trypomastigote small-surface antigen (TSSA) I and TSSA II (TSSA-WB). These antigens are expressed by T. cruzi I (TCI; now TcI) and T. cruzi II (TCII; reclassified as TcII to TcVI) parasites. TSSA-WB showed good concordance with genotyping tests. An unexpected frequency of TSSA II recognition was observed in Colombia, Venezuela, and Mexico (northern region of Latin America). In Argentina and Paraguay (southern region), immunophenotyping confirmed the already reported TCII (TcII to TcVI) dominance. The lineage distribution between these regions showed significant difference but not among countries within them (except for Colombia and Venezuela). TSSA-WB shows TCII emergence in the northern region where TCI was reported as dominant or even as the unique T. cruzi lineage infecting humans.
dc.descriptionCOL0007865
dc.format7
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.publisherBiología y Control de Enfermedades Infecciosas
dc.publisherBaltimore, Estados Unidos
dc.relationAm. J. Trop. Med. Hyg.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectEnfermedad de Chagas
dc.subjectChagas Disease
dc.subjectEnfermedades Endémicas
dc.subjectEndemic Diseases
dc.subjectTrypanosoma cruzi
dc.subjectAmérica Latina
dc.subjectLatin America
dc.subjectAnticuerpos Antiprotozoarios - sangre
dc.subjectAntibodies, Protozoan - blood
dc.subjectAntígenos de Protozoos
dc.subjectAntigens, Protozoan
dc.subjectWestern Blotting
dc.subjectBlotting, Western
dc.subjectInmunofenotipificación
dc.subjectImmunophenotyping
dc.titleImmunological identification of Trypanosoma cruzi lineages in human infection along the endemic area
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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