| dc.creator | Robledo Restrepo, Sara María | |
| dc.creator | Vélez Bernal, Iván Darío | |
| dc.creator | Schmidt, Thomas | |
| dc.date | 2021-08-04T23:18:54Z | |
| dc.date | 2021-08-04T23:18:54Z | |
| dc.date | 2018 | |
| dc.date.accessioned | 2023-08-28T19:56:04Z | |
| dc.date.available | 2023-08-28T19:56:04Z | |
| dc.identifier | 1420-3049 | |
| dc.identifier | http://hdl.handle.net/10495/21523 | |
| dc.identifier | doi:10.3390/molecules23010150 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8471123 | |
| dc.description | ABSTRACT: In search for potential therapeutic alternatives to existing treatments for cutaneous Leishmaniasis, we have investigated the effect of Arnica tincture Ph. Eur. (a 70% hydroethanolic tincture prepared from flowerheads of Arnica montana L.) on the lesions caused by infection with Leishmania braziliensis in a model with golden hamsters. The animals were treated topically with a daily single dose of the preparation for 28 days. Subsequently, the healing process was monitored by recording the lesion size in intervals of 15 days up to day 90. As a result, Arnica tincture fully cured three out of five hamsters while one animal showed an improvement and another one suffered from a relapse. This result was slightly better than that obtained with the positive control, meglumine antimonate, which cured two of five hamsters while the other three showed a relapse after 90 days. This result encourages us to further investigate the potential of Arnica tincture in the treatment of cutaneous Leishmaniasis. | |
| dc.description | COL0015099 | |
| dc.format | 7 | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | MDPI | |
| dc.publisher | Programa de Estudio y Control de Enfermedades Tropicales (PECET) | |
| dc.publisher | Basilea, Suiza | |
| dc.relation | Molecules | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by/2.5/co/ | |
| dc.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Arnica | |
| dc.subject | Leishmaniasis Cutánea | |
| dc.subject | Leishmaniasis, Cutaneous | |
| dc.subject | Medicina Tropical | |
| dc.subject | Tropical Medicine | |
| dc.title | Arnica Tincture Cures Cutaneous Leishmaniasis in Golden Hamsters | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.type | https://purl.org/redcol/resource_type/ART | |
| dc.type | Artículo de investigación | |
