Mango (Mangifera indica cv. Azúcar) antiinflammatory and chemopreventive role during colorectal carcinogenesis

dc.creatorCorrales Bernal, Andrea
dc.creatorJaramillo Zapata, Gabriela
dc.creatorRodríguez, Berardo de Jesús
dc.creatorYahia Kazuz, Elhadi
dc.creatorMaldonado Celis, María Elena
dc.date2019-08-22T19:01:47Z
dc.date2019-08-22T19:01:47Z
dc.date2016
dc.date.accessioned2023-08-28T19:55:45Z
dc.date.available2023-08-28T19:55:45Z
dc.identifierCorrales-Bernal A, Jaramillo G, Rodríguez B, Yahia-Kazuz E, Maldonado-Celis M. Mango (Mangifera indica cv. Azúcar) antiinflammatory and chemopreventive role during colorectal carcinogenesis. Emir J Food Agric. 2016; 28(10): 704-12 DOI: 10.9755/ejfa.2015-08-593
dc.identifier2079-052X
dc.identifierhttp://hdl.handle.net/10495/11716
dc.identifier10.9755/ejfa.2015-08-593
dc.identifier2079-0538
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8471025
dc.descriptionABSTRACT: Chemopreventive activities of natural compounds result in the modulation of several pathways and molecular targets. It is common to find effective potential candidates for cancer chemoprevention with anti-inflammatory properties. Mango (Mangifera indica cv. Azúcar) has shown anticarcinogenic effects and it is a source of bioactive compounds. This study evaluated the effects of mango on Aberrant Crypt Foci formation and inflammatory biomarkers after initiation of colon carcinogenesis in AOM-treated mice. Ripped mango pulp (Mangifera indica cv. Azúcar) composition was identified by HPLC. Azoxymethane-treated mice received the fruit (0.3% w/v) for eight weeks and the distal part of colon was collected and stained with methylene blue to look for aberrant crypt foci (ACF); scrapped mucosal cells were processed for prostaglandin E2 detection by ELISA; and blood levels of pro-inflammatory cytokines (interleukin-1Beta, tumor necrosis factor-alpha, interleukin 6) were also assessed by ELISA. Student’s t.test was used for the comparisons between mango treated and untreated groups. ACF formation was reduced by 67.5% and prostaglandin E2 levels were also reduced in mice which ingested the fruit. Cytokines levels were unchanged by mango consumption. In the chromatography were identified phenolic acids and Beta-carotene. Mango pulp showed chemopreventive effects through the reduction of ACF formation, by means of blocking hyperproliferation which is correlated with decreasing levels of PGE2.
dc.descriptionCOL0092964
dc.descriptionCOL0083811
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherFacultad de Alimentación y Agricultura, Universidad de los Emiratos Árabes Unidos
dc.publisherImpacto de Componentes Alimentarios en la Salud
dc.publisherGrupo de Investigación en Patobiología - QUIRÓN
dc.publisherEmiratos Árabes Unidos
dc.relationEmir J Food Agric
dc.rightsAtribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectMangiferin indica
dc.subjectColorectal cancer
dc.subjectChemoprevention
dc.subjectProstaglandin E2
dc.subjectCytokines
dc.titleMango (Mangifera indica cv. Azúcar) antiinflammatory and chemopreventive role during colorectal carcinogenesis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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