Cross-Species Immune Recognition Between Plasmodium Vivax Duffy Binding Protein Antibodies and the Plasmodium Falciparum Surface Antigen VAR2CSA

dc.creatorArango Flórez, Eliana María
dc.creatorMaestre Buitrago, Amanda Elena
dc.creatorGnidehou, Sédami
dc.creatorMitran, Catherine J.
dc.creatorBanman, Shanna
dc.creatorMena Palacios, Angie Yarleidy
dc.creatorMedawar, Evelyn
dc.creatorS. Lima, Barbara A.
dc.creatorDoritchamou, Justin
dc.creatorRajwani, Jahanara
dc.creatorJin, Albert
dc.creatorGavina, Kenneth
dc.creatorNtumngia, Francis
dc.creatorDuffy, Patrick
dc.creatorNarum, David
dc.creatorNdam, Nicaise
dc.creatorNielsen, Morten A.
dc.creatorSalanti, Ali
dc.creatorKano, Flora S.
dc.creatorCarvalho, Luzia Helena
dc.creatorAdams, John H.
dc.creatorGood, Michael F.
dc.creatorYanow, Stephanie K.
dc.date2022-04-26T19:49:44Z
dc.date2022-04-26T19:49:44Z
dc.date2019
dc.date.accessioned2023-08-28T19:54:51Z
dc.date.available2023-08-28T19:54:51Z
dc.identifier0022-1899
dc.identifierhttp://hdl.handle.net/10495/27876
dc.identifier10.1093/infdis/jiy467
dc.identifier1537-6613
dc.identifierhttps://academic.oup.com/jid/article/219/1/110/5059785?login=true
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8470767
dc.descriptionABSTRACT: Background. In pregnancy, Plasmodium falciparum parasites express the surface antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies are generally acquired during infection in pregnancy and are associated with protection from placental malaria. We observed previously that men and children in Colombia also had antibodies to VAR2CSA, but the origin of these antibodies was unknown. Here, we tested whether infection with Plasmodium vivax is an alternative mechanism of acquisition of VAR2CSA antibodies. Methods. We analyzed sera from nonpregnant Colombians and Brazilians exposed to P. vivax and monoclonal antibodies raised against P. vivax Duffy binding protein (PvDBP). Cross-reactivity to VAR2CSA was characterized by enzyme-linked immunosorbent assay, immunofluorescence assay, and flow cytometry, and antibodies were tested for inhibition of parasite binding to CSA. Results. Over 50% of individuals had antibodies that recognized VAR2CSA. Affinity-purified PvDBP human antibodies and a PvDBP monoclonal antibody recognized VAR2CSA, showing that PvDBP can give rise to cross-reactive antibodies. Importantly, the monoclonal antibody inhibited parasite binding to CSA, which is the primary in vitro correlate of protection from placental malaria. Conclusions. These data suggest that PvDBP induces antibodies that functionally recognize VAR2CSA, revealing a novel mechanism of cross-species immune recognition to falciparum malaria.
dc.description0047449
dc.format11
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.publisherSalud y Comunidad
dc.publisherOxford, Estados Unidos
dc.relationJ. Infect. Dis.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPlasmodium vivax
dc.subjectPlasmodium falciparum
dc.subjectPregnancy
dc.subjectEmbarazo
dc.subjectImmunity
dc.subjectInmunidad
dc.subjectMalaria
dc.titleCross-Species Immune Recognition Between Plasmodium Vivax Duffy Binding Protein Antibodies and the Plasmodium Falciparum Surface Antigen VAR2CSA
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


Este ítem pertenece a la siguiente institución