A Genomewide Admixture Map for Latino Populations

dc.creatorPrice, Alkes
dc.creatorPatterson, Nick
dc.creatorYu, Fuli
dc.creatorCox, David
dc.creatorWaliszewska, Alicja
dc.creatorMcDonald, Gavin
dc.creatorTandon, Arti
dc.creatorSchirmer, Christine
dc.creatorNeubauer, Julie
dc.creatorBedoya Berrío, Gabriel de Jesús
dc.creatorDuque Vélez, Constanza Elena
dc.creatorVillegas Perrasse, Alberto
dc.creatorBortolini, María Cátira
dc.creatorSalzano, Francisco Mauro
dc.creatorGallo, Carla
dc.creatorMazzotti, Guido
dc.creatorTello Ruiz, Marcela
dc.creatorRiba, Laura
dc.creatorAguilar Salinas, Carlos Alberto
dc.creatorCanizales Quinteros, Samuel
dc.creatorMenjívar Iraheta, Marta Alicia
dc.creatorKlitz, William
dc.creatorHenderson, Brian
dc.creatorHaiman, Christopher
dc.creatorWinkler, Cheryl
dc.creatorTusie Luna, Teresa
dc.creatorRuíz Linares, Andrés
dc.creatorReich, David
dc.date2022-03-19T19:58:44Z
dc.date2022-03-19T19:58:44Z
dc.date2007
dc.date.accessioned2023-08-28T19:48:59Z
dc.date.available2023-08-28T19:48:59Z
dc.identifierPrice, A., Patterson, N., Yu, F., Cox, D., Waliszewska, A., McDonald, G., Tandon, A., Schirmer, C., Neubauer, J., Bedoya, G., Duque, C., Villegas, A., Bortolini, M., Salzano, F., Gallo, C., Mazzotti, G., Tello, M., Riba, L., Aguilar, C., Canizales, S., … Reich, D. (2007). A genomewide admixture map for Latino populations. American journal of human genetics, 80(6), 1024–1036. https://doi.org/10.1086/518313
dc.identifier0002-9297
dc.identifierhttp://hdl.handle.net/10495/26745
dc.identifier10.1086/518313
dc.identifier1537-6605
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8469023
dc.descriptionABSTRACT: Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise for Latinos, who typically inherit a mix of European, Native American, and African ancestry. However, admixture mapping in Latinos has not been practical because of the lack of a map of ancestry-informative markers validated in Native American and other populations. To address this, we screened multiple databases, containing millions of markers, to identify 4,186 markers that were putatively informative for determining the ancestry of chromosomal segments in Latino populations. We experimentally validated each of these markers in at least 232 new Latino, European, Native American, and African samples, and we selected a subset of 1,649 markers to form an admixture map. An advantage of our strategy is that we focused our map on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. We evaluated the effectiveness of our map for localizing disease genes in four Latino populations from both North and South America.
dc.descriptionCOL0006723
dc.format13
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherCell Press
dc.publisherGenética Molecular (GENMOL)
dc.publisherBaltimore, Estados Unidos
dc.relationAm. J. Hum. Genet.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAlelos
dc.subjectAlleles
dc.subjectGrupo de Ascendencia Continental Africana
dc.subjectAfrican Continental Ancestry Group
dc.subjectEstudios de Casos y Controles
dc.subjectCase-Control Studies
dc.subjectMapeo Cromosómico
dc.subjectChromosome Mapping
dc.subjectCromosomas Humanos
dc.subjectChromosomes, Human
dc.subjectBases de Datos Genéticas
dc.subjectDatabases, Genetic
dc.subjectMarcadores Genéticos
dc.subjectGenetic Markers
dc.subjectPredisposición Genética a la Enfermedad
dc.subjectGenetic Predisposition to Disease
dc.subjectIndios Norteamericanos
dc.subjectIndians, North American
dc.subjectGenética de Población
dc.subjectGenetics, Population
dc.titleA Genomewide Admixture Map for Latino Populations
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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