| dc.creator | Calle Botero, Estefanía | |
| dc.creator | Calle, M. | |
| dc.creator | Cabrera, H.B. | |
| dc.creator | Jaramillo Arroyave, Daniel | |
| dc.creator | Vanegas García, Adriana Lucía | |
| dc.creator | Vásquez Duque, Gloria María | |
| dc.creator | Restrepo Escobar, Mauricio | |
| dc.creator | González Naranjo, Luis Alonso | |
| dc.creator | Hernández Zapata, Lady Johanna | |
| dc.creator | Muñoz Vahos, Carlos Horacio | |
| dc.date | 2022-02-10T21:13:27Z | |
| dc.date | 2022-02-10T21:13:27Z | |
| dc.date | 2018 | |
| dc.date.accessioned | 2023-08-28T19:43:14Z | |
| dc.date.available | 2023-08-28T19:43:14Z | |
| dc.identifier | Calle E, Calle M, Cabrera H, et alAB0660 The role of anti-neutrophil cytoplasmic autoantibody specificity for mpo or pr3 in phenotype of anca associated vasculitis: knowing the autoimmunity in latin americaAnnals of the Rheumatic Diseases 2018;77:1474. | |
| dc.identifier | 0003-4967 | |
| dc.identifier | http://hdl.handle.net/10495/25964 | |
| dc.identifier | 10.1136/annrheumdis-2018-eular.7488 | |
| dc.identifier | 1468-2060 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8467186 | |
| dc.description | ABSTRACT: Background: Antineutrophil cytoplasmic antibodies (ANCA) are present in up to
90% granulomatosis with polyangiitis, 80% microscopic polyangiitis and 70%
eosinophilic granulomatosis with polyangiitis. MPO-ANCA has been associated
with vasculitis limited to the kidney, chronic renal damage and less frequent gastrointestinal or respiratory tract involvement. PR3-ANCA are characterised by
destructive lesions of the ears, nose and throat, alveolar haemorrhage, combination of upper and/or lower respiratory tract involvement with renal compromise
and increased number of relapses. The frequency of pulmonary involvement is
similar in both serotypes, and most ANCA associated vasculitis (AAV) patients
are diagnosed between ages 50 and 70 years.
Objectives: To describe differences in clinical profiles of patients with AAV
regarding ANCA specificity against MPO or PR3 in a Colombian based adult
population
Methods: All medical records of patients with a diagnosis of AAV in two high complexity hospitals in Medellín, Colombia from January 1, 2014 to December 31,
2016 were reviewed. The clinical and demographic characteristics were
abstracted and analysed with descriptive and inferential statistics in SPSS.22
Results: Of 59 cases of AAV, 44 were positive for MPO or PR3-ANCA with male
predominance (65.5% men vs 34.5% women) and similar age at diagnosis (47
years in MPO-ANCA vs 50 in PR3-ANCA). MPO-ANCA group had more fever and
weight loss (34.8% vs 20%), arterial hypertension (34.5% vs 26.7%), hematuria
(34.5% vs 26.7%), proteinuria (31% vs 26.7%), creatinin higher than 5.6 mg/dL
(20.7 vs 13.3%), myalgias (13.8 vs 0%) pachymeningitis (7% vs 0%) and skin
compromise. PR3-ANCA patients had more arthralgias/arthritis (40% vs 31%),
escleritis (33% vs 13.8%), episcleritis (13.3% vs 0%) and uveítis (10% vs 7%).
Conclusions: In this Latin American population ANCA specificity affected the
phenotype of clinical disease. MPO-ANCA patients had more constitutional symptoms, renal and central nervous system compromise while PR3-ANCA patients
showed more articular and ocular involvement. | |
| dc.description | COL0010959 | |
| dc.format | 1 | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | BMJ Publishing Group | |
| dc.publisher | Grupo de Reumatología Universidad de Antioquia -GRUA- | |
| dc.publisher | Londres, Inglaterra | |
| dc.relation | Ann. Rheum. Dis. | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc/2.5/co/ | |
| dc.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.rights | https://creativecommons.org/licenses/by-nc/4.0/ | |
| dc.subject | Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos | |
| dc.subject | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | |
| dc.subject | Anticuerpos Anticitoplasma de Neutrófilos | |
| dc.subject | Antibodies, Antineutrophil Cytoplasmic | |
| dc.title | The role of anti-neutrophil cytoplasmic autoantibody specificity for mpo or pr3 in phenotype of anca associated vasculitis: knowing the autoimmunity in latin america | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | http://purl.org/coar/resource_type/c_dcae04bc | |
| dc.type | https://purl.org/redcol/resource_type/ARTREV | |
| dc.type | Artículo de revisión | |
