Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial

dc.creatorAgudelo Ochoa, Gloria María
dc.creatorPulgarín Zapata, Isabel Cristina
dc.creatorVelásquez Rodríguez, Claudia María
dc.creatorDuque Ramírez, Mauricio
dc.creatorNaranjo Cano, Mauricio
dc.creatorQuintero Ortiz, Mónica María
dc.creatorLara Guzmán, Oscar Javier
dc.creatorMuñoz Durango, Katalina
dc.date2019-08-22T15:06:04Z
dc.date2019-08-22T15:06:04Z
dc.date2016
dc.date.accessioned2023-08-28T19:42:54Z
dc.date.available2023-08-28T19:42:54Z
dc.identifierAgudelo-Ochoa GM, Pulgarín-Zapata IC, Velásquez-Rodriguez CM, Duque-Ramírez M, Naranjo-Cano M, et al. Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial. Journal Nutr, 2016; 146(3): 524-31.
dc.identifier1541-6100
dc.identifierhttp://hdl.handle.net/10495/11712
dc.identifier10.3945/jn.115.224774
dc.identifier0022-3166
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8467072
dc.descriptionABSTRACT: Coffee, a source of antioxidants, has controversial effects on cardiovascular health. Objective: We evaluated the bioavailability of chlorogenic acids (CGAs) in 2 coffees and the effects of their consumption on the plasma antioxidant capacity (AC), the serum lipid profile, and the vascular function in healthy adults. Methods: Thirty-eight men and 37 women with a mean 6 SD age of 38.5 6 9 y and body mass index of 24.1 6 2.6 kg/m2 were randomly assigned to 3 groups: a control group that did not consume coffee or a placebo and 2 groups that consumed 400 mL coffee/d for 8 wk containing a medium (MCCGA; 420 mg) or high (HCCGA; 780 mg) CGA content. Both were low in diterpenes (0.83 mg/d) and caffeine (193 mg/d). Plasma caffeic and ferulic acid concentrations were measured by GC, and the plasma AC was evaluated with use of the ferric-reducing antioxidant power method. The serum lipid profile, nitric oxide (NO) plasma metabolites, vascular endothelial function (flow-mediated dilation; FMD), and blood pressure (BP) were evaluated.Results: After coffee consumption (1 h and 8 wk), caffeic and ferulic acid concentrations increased in the coffee-drinking groups, although the values of the 2 groups were significantly different (P < 0.001); caffeic and ferulic acid concentrations were undetectable in the control group. At 1 h after consumption, the plasma AC in the control group was significantly lower than the baseline value (22%) and significantly increased in the MCCGA (6%) and HCCGA (5%) groups (P < 0.05). After 8 wk, no significant differences in the lipid, FMD, BP, or NO plasma metabolite values were observed between the groups. Conclusions: Both coffees, which contained CGAs and were low in diterpenes and caffeine, provided bioavailable CGAs and had a positive acute effect on the plasma AC in healthy adults and no effect on blood lipids or vascular function. The group that did not drink coffee showed no improvement in serum lipid profile, FMD, BP, or NO plasma metabolites. This trial was registered at registroclinico.sld.cu as RPCEC00000168.
dc.descriptionCOL0000407
dc.descriptionCOL0010359
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society for Nutrition
dc.publisherAlimentación y Nutrición Humana
dc.publisherGrupo de Investigación en Sustancias Bioactivas (GISB)
dc.publisherSpringfield, Estados Unidos
dc.relationJ Nutr
dc.rightsAtribución-NoComercial-SinDerivadas (CC BY-NC-ND)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCardiovascular disease
dc.subjectChlorogenic acids
dc.subjectPhenolic acids
dc.subjectOxidative stress
dc.subjectDiterpenes
dc.subjectCaffeine
dc.subjectFlow-mediated dilation
dc.subjectCholesterol
dc.titleCoffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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