Factores determinantes del estado nutricional del folato y el rol de la variante genética C677T de la enzima metilen tetrahidrofolato reductasa (MTHFR)

Determinants of folate nutritional status and the role of the genetic variation of C677T methylene tetrahydrofolate reductase (MTHFR) enzyme

dc.creatorHerrera Mejía, Julián
dc.creatorMuñoz Contreras, Angélica María
dc.creatorParra Sosa, Beatriz Elena
dc.date2021-08-30T12:53:57Z
dc.date2021-08-30T12:53:57Z
dc.date2016
dc.date.accessioned2023-08-28T19:38:29Z
dc.date.available2023-08-28T19:38:29Z
dc.identifierHerrera M, Julián, Muñoz, Angélica M, & Parra S, Beatriz E. (2016). Factores determinantes del estado nutricional del folato y el rol de la variante genética C677T de la enzima metilen tetrahidrofolato reductasa (MTHFR). Revista chilena de nutrición, 43(4), 336-345. https://dx.doi.org/10.4067/S0717-75182016000400001
dc.identifier0716-1549
dc.identifierhttp://hdl.handle.net/10495/21968
dc.identifier10.4067/S0717-75182016000400001.
dc.identifier0717-7518
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8465526
dc.descriptionABSTRACT: Folate is an essential nutrient because mammals lack biological activity to synthesize. It different factors generate folate deficiency. Recent studies have identified that the C677T variant of the enzyme methylene tetrahydrofolate reductase (MTHFR), can play a role in serum folate concentrations (SFC) and red cell folate (RCF). The aim of this rewiev was to actualice some generalities of folate metabolism, factors related to its deficiency, biochemical indicators used to assess the nutritional status of folate and role of the C677T polymorphism of the MTHFR enzyme on the cycle of folate and methionine. It is necessary to design studies with representative samples corroborating the effect of polymorphisms on biochemical indicators of nutritional status of folate and determine the dose-response effect and contribute to modify the nutritional recommendations with the necessary scientific evidence.
dc.descriptionCOL0000407
dc.format10
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languagespa
dc.publisherSociedad Chilena de Nutrición, Bromatología y Toxicología
dc.publisherAlimentación y Nutrición Humana
dc.publisherSantiago de Chile, Chile
dc.relationRev. Chil. Nutr.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectMethylenetetrahydrofolate Reductase (NADPH2)
dc.subjectMetilenotetrahidrofolato Reductasa (NADPH2)
dc.subjectFolatos
dc.titleFactores determinantes del estado nutricional del folato y el rol de la variante genética C677T de la enzima metilen tetrahidrofolato reductasa (MTHFR)
dc.titleDeterminants of folate nutritional status and the role of the genetic variation of C677T methylene tetrahydrofolate reductase (MTHFR) enzyme
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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