| dc.creator | Ayala Ramírez, Paola | |
| dc.creator | Machuca-Acevedo, Catalina | |
| dc.creator | Gámez, Tatiana | |
| dc.creator | Quijano Gómez, Sandra Milena | |
| dc.creator | Barreto Prieto, Alfonso | |
| dc.creator | Silva Herrera, Jaime Luis | |
| dc.creator | Olaya Contreras, Mercedes | |
| dc.creator | García-Robles, Reggie | |
| dc.creator | Rivatrem | |
| dc.date | 2022-05-31T17:18:22Z | |
| dc.date | 2023-05-11T19:21:40Z | |
| dc.date | 2022-05-31T17:18:22Z | |
| dc.date | 2023-05-11T19:21:40Z | |
| dc.date | 2021-07-23 | |
| dc.date.accessioned | 2023-08-24T10:46:24Z | |
| dc.date.available | 2023-08-24T10:46:24Z | |
| dc.identifier | https://www.frontiersin.org/articles/10.3389/fphys.2021.708824/full | |
| dc.identifier | 1664-042X | |
| dc.identifier | https://hdl.handle.net/20.500.12032/113797 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8418897 | |
| dc.description | Preeclampsia (PE) is a hypertensive disorder that affects 2–8% of pregnancies and is one
of the main causes of fetal, neonatal, and maternal mortality and morbidity worldwide.
Although PE etiology and pathophysiology remain unknown, there is evidence that the
hyperactivation of maternal immunity cells against placental cells triggers trophoblast
cell apoptosis and death. It has also been reported that placenta-derived extracellular
vesicles (EV) carry Fas ligand (FasL) and Tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and trigger apoptosis in Jurkat T cells. This study aimed
to quantify and compare FasL and TRAIL expression in EV derived from cultures
of placenta explants from women with PE (early versus late) and women with
uncomplicated pregnancies. Also, the study assessed EV capacity to induce apoptosis
in Jurkat T cells. The authors isolated EV from placenta explant cultures, quantified
FasL and TRAIL using ELISA, and analyzed EV apoptosis-inducing capability by flow
cytometry. Results showed increased FasL and TRAIL in EV derived from placenta
of women with PE, and increased EV apoptosis-inducing capability in Jurkat T cells.
These results offer supporting evidence that EV FasL and TRAIL play a role in the
pathophysiology of PE. | |
| dc.format | PDF | |
| dc.format | application/pdf | |
| dc.rights | http://creativecommons.org/licenses/by-nc/4.0/ | |
| dc.subject | Pregnancy | |
| dc.subject | Hypertension Disorder Complicating Pregnancy | |
| dc.subject | Exosome (Vesicle) | |
| dc.subject | Apoptosis | |
| dc.subject | Placental Culture | |
| dc.title | Assessment of placental extracellular vesicles-associated fas ligand and TNF-related apoptosis-inducing ligand in pregnancies complicated by early and late onset preeclampsia | |
| dc.coverage | Colombia | |
| dc.coverage | 2018 | |
