dc.contributor | Bravo Calderón, Diego Mauricio | |
dc.creator | Quizhpi Quito, Andrea Soledad | |
dc.date.accessioned | 2023-05-25T15:38:21Z | |
dc.date.accessioned | 2023-08-10T15:11:50Z | |
dc.date.available | 2023-05-25T15:38:21Z | |
dc.date.available | 2023-08-10T15:11:50Z | |
dc.date.created | 2023-05-25T15:38:21Z | |
dc.date.issued | 2023-05-25 | |
dc.identifier | http://dspace.ucuenca.edu.ec/handle/123456789/41960 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8152183 | |
dc.description.abstract | Objective: To conduct a systematic review of the possible association between transforming growth factor B3 (TGFB3) and fibroblast growth factors (FGFs) gene polymorphisms and non-syndromic cleft lip with or without cleft palate (NSCL/P). Methods: Two reviewers independently screened studies by examining all titles and abstracts. Studies were included if they met the following criteria: the outcome of interest was NSCL/P; the polymorphisms studied were TGFB3 and FGF; they presented sufficient data, i.e., allele/genotype frequency between cases and controls; or their odds ratio (OR) with 95% confidence interval (CI). Study quality was independently assessed by a risk of bias assessment for genetic association studies. Results: Based on the inclusion criteria we have selected a total of 6 articles (4 for TGFB and 2 for FGF). Particularly for the TGFB gene we have found significant results in exon 4 in the variant g.15812T>G, and in the SNP rs2300607 A/T, in the distribution between cases and controls. On the other hand, for the FGF gene we observed a statistically significant in the genotype rs34010 CA. Conclusion: None of the genetic variations that show association is verified in different populations, therefore, there is not enough scientific validation regarding the association between TGFB and FGF polymorphism and NSCL/P. The findings of the different studies suggest the need for further investigations with samples composed of a larger number of individuals in different populations, which should be performed with all the standards for genetic studies, thus allowing an understanding of the molecular basis of the disease. | |
dc.language | spa | |
dc.publisher | Universidad de Cuenca | |
dc.relation | ODONOR;38 | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights | openAccess | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | |
dc.subject | Odontología | |
dc.subject | Polimorfismo | |
dc.subject | Fisura labial | |
dc.subject | Paladar | |
dc.subject | Genes | |
dc.title | Association of TGFB3 AND FGFs gene polymorphisms with cleft lip with or without cleft palate. A systematic review | |
dc.type | bachelorThesis | |