Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines

dc.creatorFischer, Geferson
dc.creatorPaulino, Niraldo
dc.creatorRibeiro, Maria Cristina Marcucci
dc.creatorSiedler, Bianca Sica
dc.creatorMunhoz, Lívia Silveira
dc.creatorFinger, Paula Fonseca
dc.creatorVargas, Gilberto D`Avila
dc.creatorHübner, Sílvia de Oliveira
dc.creatorVidor, Telmo
dc.creatorRoehe, Paulo Michel
dc.date2011-05-04T06:00:15Z
dc.date2009
dc.identifier0074-0276
dc.identifierhttp://hdl.handle.net/10183/28852
dc.identifier000765451
dc.descriptionAdjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity.
dc.formatapplication/pdf
dc.languageeng
dc.relationMemórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Vol. 105, no. 7 (nov. 2010), p. 908-913
dc.rightsOpen Access
dc.subjectPropolis
dc.subjectPhenolic compounds
dc.subjectVaccines
dc.subjectHumoral immunity
dc.subjectCellular immunity
dc.subjectPropolis
dc.subjectCompostos fenólicos
dc.subjectVacinas
dc.subjectImunidade celular
dc.subjectImunidade humoral
dc.titleGreen propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines
dc.typeArtigo de periódico
dc.typeNacional


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