Pharmacological action of tick saliva upon haemostasis and the neutralization ability of sera from repeatedly infested hosts

dc.creatorReck Junior, José
dc.creatorOliveira, Markus Berger
dc.creatorMarks, Fernanda Simone
dc.creatorZingali, Russolina Benedeta
dc.creatorCanal, Cláudio Wageck
dc.creatorFerreira, Carlos Alexandre Sanchez
dc.creatorGuimaraes, Jorge Almeida
dc.creatorTermignoni, Carlos
dc.date2011-01-21T05:59:03Z
dc.date2009
dc.identifier0031-1820
dc.identifierhttp://hdl.handle.net/10183/27465
dc.identifier000750325
dc.descriptionTicks are blood-feeding arthropods widely distributed in the world and vectors of several diseases. As haematophagy demands evasion strategies and repeatedly infested hosts develop protective immune responses, we investigated the mechanisms of the Rhipicephalus (Boophilus) microplus saliva anti-haemostatic activity and the possible relationship between the acquired natural anti-tick host resistance and anti-haemostatic action. For this purpose, we studied the effects of R. microplus saliva on different pathways of haemostasis and tested whether repeated infested bovine sera (RIBS) are able to abolish salivary anti-haemostatic activities. R. microplus saliva (i) displays inhibitory activity upon collagen-induced platelet aggregation; (ii) inhibits the induction of endothelial pro-coagulant state ; and (iii) reduces thrombogenesis in vivo. RIBS were shown to be able to partially block the delay of coagulation and the anti-thrombotic effect of saliva, and to totally abolish the modulation of endothelium activation. Conversely, RIBS has no effect on the inhibition of platelet aggregation. These results show, for the first time, the neutralization ability of sera from acquired resistance hosts against tick antihaemostatics. Moreover, this is the first report of a haematophagous parasite able to modulate endothelial cell procoagulant state, and addresses the presence of anti-platelet and anti-thrombotic activity in R. microplus saliva.
dc.formatapplication/pdf
dc.languageeng
dc.relationParasitology. Cambridge, United Kingdom. Vol. 136, no. 11 (Sept. 2009), p. 1339-1349
dc.rightsOpen Access
dc.subjectBoophilus microplus
dc.subjectCarrapatos
dc.subjectHemostasia
dc.subjectCoagulação sanguínea
dc.subjectBioquímica
dc.subjectRhipicephalus (Boophilus) microplus
dc.subjectTick
dc.subjectHaematophagous
dc.subjectHaemostasis
dc.subjectCoagulation
dc.subjectPlatelet
dc.subjectEndothelium
dc.subjectThrombosis
dc.subjectBovine resistance
dc.titlePharmacological action of tick saliva upon haemostasis and the neutralization ability of sera from repeatedly infested hosts
dc.typeArtigo de periódico
dc.typeEstrangeiro


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