Evaluation of lipases in the desymmetrization of meso-exo-3,5-dihydroxymethylenetricyclo [5.2.1.02,6] decane and the synthesis of chiral derivatives

dc.creatorCosta, Valentim Emilio Uberti
dc.creatorPohlmann, Adriana Raffin
dc.creatorTebaldi, Marli Luiza
dc.date2010-07-13T04:18:51Z
dc.date2004
dc.identifier0103-5053
dc.identifierhttp://hdl.handle.net/10183/24556
dc.identifier000414248
dc.descriptionA dessimetrização mais eficiente do composto meso-exo-3,5-dihidroximetilenotriciclo[ 5.2.1.02,6]decano foi com a lipase da Pseudomonas cepacia (PS–C ‘Amano’ II) em acetato de vinila, quando obteve-se alto rendimento químico (93%) e excelente excesso enantiomérico (ee ³ 99%), determinado por cromatografia gasosa em coluna quiral. Desse sistema quiral, foram preparados derivados enantiopuros com potenciais aplicações como intermediários sintéticos.
dc.descriptionMeso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.02,6]decane was efficiently desymmetrized by the lipase from Pseudomonas cepacia (PS–C ‘Amano’ II) in vinyl acetate in high yields (93%) and with excellent enantiomeric excesses (ee ³ 99% by chiral GC). Chiral synthons for asymmetric synthesis were synthesized from this enantiopure compoun
dc.formatapplication/pdf
dc.languageeng
dc.relationJournal of the Brazilian Chemical Society. São Paulo. Vol. 15, n. 1 (2004), p. 22-27
dc.rightsOpen Access
dc.subjectLipases
dc.subjectEnzymatic catalysis
dc.subjectDesymmetrization
dc.subjectChiral compounds
dc.subjectLipase
dc.subjectCatálise enzimática
dc.subjectSíntese orgânica
dc.subjectQuirais : Sintese organica
dc.titleEvaluation of lipases in the desymmetrization of meso-exo-3,5-dihydroxymethylenetricyclo [5.2.1.02,6] decane and the synthesis of chiral derivatives
dc.typeArtigo de periódico
dc.typeNacional


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