| dc.creator | Mentz, Marcia Bohrer | |
| dc.creator | Teixeira, Carlos Graeff | |
| dc.creator | Garrido, Cinara Tentardini | |
| dc.date | 2010-06-01T04:17:57Z | |
| dc.date | 2004 | |
| dc.identifier | 0036-4665 | |
| dc.identifier | http://hdl.handle.net/10183/23154 | |
| dc.identifier | 000468874 | |
| dc.description | Abdominal angiostrongyliasis is a zoonotic infection produced by a metastrongylid intra-arterial nematode, Angiostrongylus costaricensis. Human accidental infection may result in abdominal lesions and treatment with anti-helminthics is contra-indicated because of potential higher morbidity with excitement or death of worms inside vessels. To evaluate the effect of mebendazole on localization of the worms, male Swiss mice, 5 week-old, were infected with 10 third stage larvae per animal. Twelve infected mice were treated with oral mebendazol, at 5 mg/kg/day, for 5 consecutive days, begining 22 days after inoculation. As control groups, 12 infected but non-treated mice and other 12 non-infected and non-treated mice were studied. The findings at necropsy were, respectively for the treated (T) and control (C) groups: 92% and 80% of the worms were inside the cecal mesenteric arterial branch; 8% and 10% were located inside the aorta. Only in the group C some worms (10%) were found inside the portal vein or splenic artery. These data indicate that treatment with mebendazole does not lead to distal or ectopic migration of A. costaricensis worms. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.relation | Revista do Instituto de Medicina Tropical de São Paulo = Journal of the São Paulo Institute of Tropical Medicine. São Paulo, SP. Vol. 46, n. 2 (2004), p. 73-75 | |
| dc.rights | Open Access | |
| dc.subject | Angiostrongylus costaricencis | |
| dc.subject | Adult stage | |
| dc.subject | Migration | |
| dc.subject | Mebendazole | |
| dc.subject | Parasitologia | |
| dc.title | Treatment with mebendazole is not associated with distal migration of adult Angiostrongylus costaricensis in the murine experimental infection | |
| dc.type | Artigo de periódico | |
| dc.type | Nacional | |
