Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01)

dc.creatorCaramelli, Paulo
dc.creatorChaves, Marcia Lorena Fagundes
dc.creatorEngelhardt, Eliase
dc.creatorMachado, João Carlos B.
dc.creatorSchultz, Rodrigo R.
dc.creatorVale, Francisco A. C.
dc.creatorCharchat, Helenice
dc.date2010-05-12T04:16:35Z
dc.date2004
dc.identifier0004-282X
dc.identifierhttp://hdl.handle.net/10183/21888
dc.identifier000507516
dc.descriptionObjective: To investigate the effects of galantamine on the performance of patients with mild to moderate Alzheimer’s disease (AD) in a computerized neuropsychological test battery (CNTB). Method:Thirty-three patients with probable AD were treated with galantamine for three months and evaluated in a prospective, open-label, multi-center study. The CNTB and the ADAS-Cog were administered at baseline and after 12 weeks. The CNTB includes reaction time tests to evaluate attention, implicit and episodic memory for faces and words. Statistical comparisons were performed between the results in week 12 versus baseline. Patients who did not reach the therapeutic doses were excluded from the efficacy analysis. Results: Four patients (12.1%) were excluded from the analysis either because of treatment discontinuation (n=3) or because a therapeutic dose was not reached (n=1).The remaining 29 patients were treated with doses of 24 mg/day (n=22) and 16 mg/day (n=7). After 12 weeks, significant reductions in reaction time were seen in the test of episodic memory for faces (p=0.023) and in the test of two-choice reaction time (p=0.039) of the CNTB. Conclusion: Treatment with galantamine produced improvement in computerized tests of attention and episodic memory after 12 weeks, leading to statistically significant reduction in the reaction times.
dc.formatapplication/pdf
dc.languageeng
dc.relationArquivos de neuro-psiquiatria. Vol. 62, n. 2B (jun. 2004), p. 379-384
dc.rightsOpen Access
dc.subjectAlzheimer’s disease
dc.subjectClinical trial
dc.subjectGalantamine
dc.subjectComputerized neuropsychological tests
dc.subjectAttention
dc.subjectMemory
dc.subjectDoença de Alzheimer
dc.subjectNeurofisiologia
dc.titleEffects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01)
dc.typeArtigo de periódico
dc.typeNacional


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