| dc.creator | Silva, Adriana Lourenço da | |
| dc.creator | Elisabetsky, Elaine | |
| dc.date | 2010-04-24T04:15:42Z | |
| dc.date | 2001 | |
| dc.identifier | 0100-879X | |
| dc.identifier | http://hdl.handle.net/10183/21203 | |
| dc.identifier | 000576295 | |
| dc.description | Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the headdipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 ± 2.37 compared to 33.83 ± 4.39, P<0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 ± 4.39 to 54 ± 3.8, P<0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30% propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.relation | Revista brasileira de pesquisas médicas e biológicas = Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 4 (Apr. 2001), p. 545-547 | |
| dc.rights | Open Access | |
| dc.subject | Farmacologia clínica | |
| dc.subject | Screening | |
| dc.subject | Anxiolytic drugs | |
| dc.subject | Propylene glycol | |
| dc.subject | Diazepam | |
| dc.subject | Solvents | |
| dc.subject | Hole-board | |
| dc.title | Interference of propylene glycol with the hole-board test | |
| dc.type | Artigo de periódico | |
| dc.type | Nacional | |
