dc.creatorZanatta, Marilene de Souza
dc.creatorQuillfeldt, Jorge Alberto
dc.creatorSchaeffer, Evelin Lisete
dc.creatorSchmitz, Paulo Kroeff
dc.creatorQuevedo, João Luciano de
dc.creatorMedina, Jorge Horácio
dc.creatorIzquierdo, Ivan Antonio
dc.date2010-04-24T04:15:41Z
dc.date1997
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/10183/21199
dc.identifier000553945
dc.descriptionA total of 182 young adult male Wistar rats were bilaterally implanted with cannulae into the CA1 region of the dorsal hippocampus and into the amygdaloid nucleus, the entorhinal cortex, and the posterior parietal cortex. After recovery, the animals were trained in a stepdown inhibitory avoidance task. At various times after training (0, 30, 60 or 90 min) the animals received a 0.5-μl microinfusion of vehicle (saline) or 0.5 μg of muscimol dissolved in the vehicle. A retention test was carried out 24 h after training. Retention test performance was hindered by muscimol administered into both the hippocampus and amygdala at 0 but not at 30 min posttraining. The drug was amnestic when given into the entorhinal cortex 30, 60 or 90 min after training, or into the parietal cortex 60 or 90 min after training, but not before. These findings suggest a sequential entry in operation, during the posttraining period, of the hippocampus and amygdala, the entorhinal cortex, and the posterior parietal cortex in memory processing.
dc.formatapplication/pdf
dc.languageeng
dc.relationRevista brasileira de pesquisas médicas e biológicas = Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 30, n. 2 (1997), p. 235-240
dc.rightsOpen Access
dc.subjectTonsila do cerebelo
dc.subjectMemória
dc.subjectHipocampo
dc.subjectCórtex cerebral
dc.subjectMemory consolidation
dc.subjectHippocampus and amygdala
dc.subjectEntorhinal cortex
dc.subjectParietal cortex
dc.titleInvolvement of the hippocampus, amygdala, entorhinal cortex in memory consolidation
dc.typeArtigo de periódico
dc.typeNacional


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