Lung clearance of 99m TC-DTPA in systemic lupus erythematosus

dc.creatorDalcin, Paulo de Tarso Roth
dc.creatorMenna Barreto, Sérgio Saldanha
dc.creatorCunha, Renato Duarte da
dc.creatorXavier, Ricardo Machado
dc.creatorBrenol, João Carlos Tavares
dc.creatorMarroni, Belmonte Juarez
dc.date2010-04-24T04:15:28Z
dc.date2002
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/10183/21143
dc.identifier000329176
dc.descriptionThe early demonstration of lung involvement in systemic lupus erythematosus (SLE) patients is a difficult but important task. In the present study we attempted to identify abnormalities in pulmonary clearance of 99mTc-DTPA in SLE, correlating their clearance data with clinical findings and disease activity. Forty-six consecutive SLE patients with and without active disease (LACC score) and 30 normal volunteers were studied. All subjects were submitted to pulmonary scintigraphy with 99mTc-DTPA to evaluate the pulmonary clearance, and to a chest X-ray, and SLE patients were submitted to tests of disease activity, spirometry, arterial blood gases and tests to assess acute-phase proteins. Pulmonary clearance was faster in SLE patients with active disease when compared to normal controls [half-life of 67.04 min (51.52-82.55 min) in active SLE versus 85.87 min (78.85- 92.87 min) in controls, P<0.05] and there was a higher frequency of abnormal clearance rates in patients with active disease (11 of 26 patients, 42.3%) when compared with SLE patients without disease activity (2 of 20 patients, 10%) (P = 0.04). A significant correlation was observed between the clearance rates and cough (P<0.05), but not between the clearance rates and dyspnea symptoms or radiological findings, duration of SLE disease, antinuclear antibody titers and patterns, C-reactive protein or anti-double stranded DNA antibodies. We conclude that the pulmonary clearance of 99mTc-DTPA is increased in SLE patients with active disease.
dc.formatapplication/pdf
dc.languageeng
dc.relationBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 35, no. 6 (June 2002), p. 663-668
dc.rightsOpen Access
dc.subjectLupus eritematoso sistêmico
dc.subjectPulmão
dc.subjectFluxo sanguíneo regional
dc.subjectPermeabilidade capilar
dc.subjectEstudos de casos e controles
dc.subjectPulmonary epithelial permeability
dc.subjectLung clearance
dc.subjectTechnetium-99m-labeled diethylenetriamine pentaacetic acid
dc.subjectSystemic lupus erythematosus
dc.titleLung clearance of 99m TC-DTPA in systemic lupus erythematosus
dc.typeArtigo de periódico
dc.typeNacional


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