| dc.creator | Wolff, Fernando Herz | |
| dc.creator | Nhuch, Claudio | |
| dc.creator | Stefani, Luciana Paula Cadore | |
| dc.creator | Glitz, Cristina Luce | |
| dc.creator | Lhullier, Francisco Luiz Rodrigues | |
| dc.creator | Furlanetto, Tania Weber | |
| dc.date | 2010-04-16T09:10:08Z | |
| dc.date | 2001 | |
| dc.identifier | 1413-8670 | |
| dc.identifier | http://hdl.handle.net/10183/19464 | |
| dc.identifier | 000308874 | |
| dc.description | Adrenocortical insufficiency is a serious complication of AIDS. Usually, integrity of the hypothalamo-pituitary-adrenal (HPA) axis in AIDS patients is assessed by measuring basal cortisol levels and cortisol response to 250 g of ACTH. Recent studies suggest that a lower ACTH dose increases the sensitivity of the procedure. In the present study, we investigated the prevalence of adrenal hypofunction in AIDS patients using a low-dose ACTH test (1 g), evaluated the clinical characteristics that might suggest this diagnosis, and the diseases and/or drugs that could be associated with it. We prospectively evaluated 63 very ill AIDS patients and 16 normal controls. A standard examination assessed the presence of signs and symptoms of adrenal insufficiency. Blood samples were collected before and 30 and 40 minutes after an injection of 1 g 1-24 ACTH. No opportunistic disease, signs, symptoms or drugs were associated with an abnormal cortisol response to ACTH. The lowest stimulated cortisol level in the control group was 18.5 g/dL; cortisol levels ≥18 g/dL were taken to indicate a normal HPA axis. Test results revealed that 12/ 63 AIDS patients (19%) had an abnormal HPA axis. With these data in mind, we suggest a prospective adrenal function evaluation of all severely ill AIDS patients. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.relation | The Brazilian journal of infectious diseases. Vol. 5, n. 2 (2001), p. 53-59 | |
| dc.rights | Open Access | |
| dc.subject | AIDS | |
| dc.subject | Adrenal insufficiency | |
| dc.subject | ACTH | |
| dc.subject | Cortisol | |
| dc.subject | Síndrome de imunodeficiência adquirida | |
| dc.title | Low-dose adrenocorticotropin test in patients with the acquired immunodeficiency | |
| dc.type | Artigo de periódico | |
| dc.type | Nacional | |
