Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron. (Crocus sativus L.)

dc.creatorFIKRAT ABDULLAEV JAFAROVA
dc.creatorLETICIA RIVERON NEGRETE
dc.creatorHERIBERTO CABALLERO ORTEGA
dc.creatorJUAN MANUEL HERNANDEZ LOPEZ
dc.creatorELEAZAR ISRAEL PEREZ LOPEZ
dc.creatorROGELIO GREGORIO PEREDA MIRANDA
dc.creatorJESUS JAVIER ESPINOSA AGUIRRE
dc.date2003
dc.date.accessioned2023-07-25T16:15:56Z
dc.date.available2023-07-25T16:15:56Z
dc.identifier10.1016/S0887-2333(03)00098-5
dc.identifierhttp://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3112
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7805223
dc.descriptionSaffron is harvested from the dried, dark red stigmas of Crocus sativus L. flowers. It is used as a spice for flavoring and coloring food and as a perfume. It is often used for treating several diseases. We assessed the antimutagenic, comutagenic and cytotoxic effects of saffron and its main ingredients using the Ames/Salmonella test system, two well known mutagens (BP, 2AA), the in vitro colony formation assay and four different cultured human normal (CCD-18Lu) and malignant (HeLa, A-204 and HepG2) cells. When only using the TA98 strain in the Ames/Salmonella test system, saffron showed non-mutagenic, as well as non-antimutagenic activity against BP-induced mutagenicity, and demonstrated a dose-dependent co-mutagenic effect on 2-AA-induced mutagenicity. The saffron component responsible for this unusual comutagenic effect was safranal. In the in vitro colony formation test system, saffron displayed a dose-dependent inhibitory effect only against human malignant cells. All isolated carotenoid ingredients of saffron demonstrated cytotoxic activity against in vitro tumor cells. Saffron crocin derivatives possessed a stronger inhibitory effect on tumor cell colony formation. Overall, these results suggest that saffron itself, as well as its carotenoid components might be used as potential cancer chemopreventive agents. © 2003 Elsevier Ltd. All rights reserved.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPergamon Press
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceToxicology in Vitro 17(5 y 6):731-736
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectAntimutagénicos - Toxicidad
dc.subjectSupervivencia celular - Efectos de drogas
dc.subjectCrocus - Toxicidad
dc.subjectPruebas de mutagenicidad - Métodos
dc.subjectExtractos vegetales - Toxicidad
dc.subjectSalmonella typhimurium - Genética
dc.subjectCélulas madre - Efectos de drogas
dc.subjectAntimutagenic agents - Toxicity
dc.subjectCell Survival - Drug effects
dc.subjectCrocus - Toxicity
dc.subjectMutagenicity tests - Methods
dc.subjectPlant Extracts - Toxicity
dc.subjectSalmonella typhimurium - Genetics
dc.subjectStem Cells - Drug effects
dc.subjectAzafrán Crocus sativus
dc.subjectCitotoxicidad
dc.subjectMutagenicidad
dc.subjectCo-mutagenicidad
dc.subjectSaffron Crocus sativus
dc.subjectCytotoxicity
dc.subjectMutagenicity
dc.subjectCo-mutagenicity
dc.titleUse of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron. (Crocus sativus L.)
dc.typeinfo:eu-repo/semantics/article


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