Pontine and cerebellar norepinephrine content in adult rats recovering from focal cortical injury.

dc.creatorRIGOBERTO GONZALEZ PIÑA
dc.date2006
dc.date.accessioned2023-07-25T16:15:43Z
dc.date.available2023-07-25T16:15:43Z
dc.identifier10.1007/s11064-006-9196-6
dc.identifierhttp://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3121
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7805130
dc.descriptionNorepinephrine (NE) plays an important role in motor recovery after brain damage. Most studies concerning NE activity have been performed in the cerebellum, while the role of the pons, the site where the norepinephrinergic locus coeruleus is located, has not yet been elucidated. For this work, we studied the changes in cerebellar and pontine NE content in sham-operated (n = 17), motor cortex injured (n = 6) and recovered rats (n = 12). Motor effects were assessed by means of footprint analysis and sensorimotor evaluation. It was found that after cortical brain damage, the stride length decreases while the stride angle increases after 6 h post-surgery, while the sensorimotor evaluation showed an increase in the motor deficit. Recovery was observed after 24 h. NE content increased in the pons after 6 h and returned to normal levels in recovered rats, with no significant changes observed in the cerebellum. Based on the functional remote inhibition, it is possible that NE exerts an autoinhibitory effect in the pons after motor cortical ablation. On the other hand, the absence of an effect in the cerebellum suggests that cerebellar NE activity related to damage and/or recovery is limited to discrete areas of the structure. © 2006 Springer Science+Business Media, LLC.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceNeurochemical Research 31(12):1443 - 1449
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectCerebelo - Metabolismo - Ratas
dc.subjectCerebelo - Fisiopatología - Ratas
dc.subjectLateralidad funcional - Fisiología - Ratas
dc.subjectTécnicas in vitro - Ratas
dc.subjectLocomoción - Fisiología - Ratas
dc.subjectCorteza motora - Lesiones - Ratas
dc.subjectCorteza motora - Fisiopatología - Ratas
dc.subjectNorepinefrina - Metabolismo - Ratas
dc.subjectPuente - Metabolismo - Ratas
dc.subjectPuente - Fisiopatología - Ratas
dc.subjectRatas wistar
dc.subjectCerebellum - Metabolism - Rats
dc.subjectCerebellum - Physiopathology - Rats
dc.subjectFunctional laterality - Physiology - Rats
dc.subjectIn vitro techniques - Rats
dc.subjectLocomotion - Physiology - Rats
dc.subjectMotor cortex - Injuries - Rats
dc.subjectMotor cortex - Physiopathology - Rats
dc.subjectNorepinephrine - Metabolism - Rats
dc.subjectPons - Metabolism- Rats
dc.subjectPons - Physiopathology - Rats
dc.subjectNorepinefrina
dc.subjectLesión cerebral
dc.subjectCerebelo
dc.subjectProtuberancia
dc.subjectDiasquisis
dc.subjectNorepinephrine
dc.subjectBrain injury
dc.subjectPons
dc.subjectCerebellum
dc.subjectDiaschisis
dc.titlePontine and cerebellar norepinephrine content in adult rats recovering from focal cortical injury.
dc.typeinfo:eu-repo/semantics/article


Este ítem pertenece a la siguiente institución