Gonadectomy and progesterone treatment induce protection in murine cysticercosis.

dc.creatorJOSE ANTONIO VARGAS VILLAVICENCIO
dc.creatorCARLOS LARRALDE RANGEL
dc.creatorJORGE MORALES MONTOR
dc.date2006
dc.date.accessioned2023-07-25T16:15:38Z
dc.date.available2023-07-25T16:15:38Z
dc.identifier10.1111/j.1365-3024.2006.00906.x
dc.identifierhttp://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3118
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7805098
dc.descriptionThe effects of progesterone on castrated mice of both sexes infected with Taenia crassiceps cysticerci were studied. Gonadectomy and treatment with progesterone before infection decreased parasite loads by 100% compared with intact uninfected mice. mRNA levels of IFN gamma and IL-2 (typically associated to Th1-like profiles) were markedly decreased in infected gonadectomized (Gx) mice, whereas progesterone treatment of infected Gx mice did not affected its expression. mRNA levels of IL-4, and IL-10 (typically associated with Th2-like profiles) were reduced by gonadectomy, whereas restitution with progesterone did not affected this pattern in infected Gx progesterone-treated mice. Infection markedly induced expression of progesterone receptor isoform A in splenocytes of Gx mice (5-fold), whereas isoform B had no changes. Progesterone metabolism to dehydroepiandrosterone (DHEA) in Gx animals was increased 3-fold only in infected progesterone-treated uninfecteds of both sexes, but was not detectable in infected Gx progesterone-treated mice. Conversely, DHEA levels increased 100-fold in infected Gx progesterone-treated mice. However, androgen receptor expression in splenocytes of male mice showed a reduction by gonadectomy, and by infection, whereas in females AR expression showed no changes in the different mouse groups. These results suggest that progesterone, through its metabolism to DHEA, negatively affects the establishment, growth, and reproduction of Taenia crassiceps, by a mechanism that does not implicate a classic genomic pathway involving a nuclear androgen receptor.
dc.formatapplication/pdf
dc.languagespa
dc.publisherWiley
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceParasite Immunology 28(12):667-674
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectAdyuvantes inmunológicos - Metabolismo
dc.subjectAdyuvantes inmunológicos - Farmacologia
dc.subjectCisticercosis - Parasitología
dc.subjectCisticercosis - Efectos de drogas
dc.subjectDeshidroepiandrosterona - Metabolismo
dc.subjectDeshidroepiandrosterona - Farmacología
dc.subjectRatones consanguíneos BALB C - Ratones
dc.subjectOrquiectomía
dc.subjectProgesterona - Administración & dosificación
dc.subjectProgesterona - Metabolismo
dc.subjectProgesterona - Uso terapéutico
dc.subjectTaenia - Efectos de drogas
dc.subjectTaenia - Crecimiento & desarrollo
dc.subjectResultado del tratamiento
dc.subjectAdjuvants, immunologic - Metabolism
dc.subjectAdjuvants, immunologic - Pharmacology
dc.subjectCysticercosis - Immunology
dc.subjectCysticercosis - Parasitology
dc.subjectCysticercus - Drug effects
dc.subjectDehydroepiandrosterone- Metabolism
dc.subjectDehydroepiandrosterone - Pharmacology
dc.subjectMice, inbred BALB C
dc.subjectOrchiectomy
dc.subjectOvariectomy
dc.subjectProgesterone - Administration & dosage
dc.subjectProgesterone - Metabolism
dc.subjectProgesterone - Therapeutic use
dc.subjectProgestins - Administration & dosage
dc.subjectProgestins - Metabolism
dc.subjectProgestins - Therapeutic use
dc.subjectTaenia - Drug effects
dc.subjectTaenia - Growth & development
dc.subjectTreatment outcome
dc.subjectCisticercosis
dc.subjectInmunoendocrinos
dc.subjectMetabolismo
dc.subjectProgesterona
dc.subjectCysticercosis
dc.subjectImmunoendocrine
dc.subjectProgesterone
dc.subjectTaenia
dc.titleGonadectomy and progesterone treatment induce protection in murine cysticercosis.
dc.typeinfo:eu-repo/semantics/article


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