Comparative genomics of DNA-binding transcription factors in archaeal and bacterial organisms

dc.creatorLuis Martinez Liu
dc.creatorRafael Hernandez Guerrero
dc.creatorNANCY RIVERA GOMEZ
dc.creatorMario Alberto Martínez Núñez
dc.creatorPedro Javier Escobar Turriza
dc.creatorEveline Peeters
dc.creatorPerez-Rueda Ernesto
dc.date2021
dc.date.accessioned2023-07-21T19:19:52Z
dc.date.available2023-07-21T19:19:52Z
dc.identifierhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/2135
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7737669
dc.descriptionArchaea represent a diverse phylogenetic group that includes free-living, extremophile, mesophile, symbiont, and opportunistic organisms. These prokaryotic organisms share a high significant similarity with the basal transcriptional machinery of Eukarya, and they share regulatory mechanisms with Bacteria, such as operonic organization and DNA-binding transcription factors (TFs). In this work, we identified the repertoire of TFs in 415 archaeal genomes and compared them with their counterparts in bacterial genomes. The comparisons of TFs, at a global level and per family, allowed us to identify similarities and differences between the repertoires of regulatory proteins of bacteria and archaea. For example, 11 of 62 families are more highly abundant in archaea than bacteria, and 13 families are abundant in bacteria but not in archaea and 38 families have similar abundances in the two groups. In addition, we found that archaeal TFs have a lower isoelectric point than bacterial proteins, i.e., they contain more acidic amino acids, and are smaller than bacterial TFs. Our findings suggest a divergence occurred for the regulatory proteins, even though they are common to archaea and bacteria. We consider that this analysis contributes to the comprehension of the structure and functionality of regulatory protein of archaeal organisms.
dc.formatapplication/pdf
dc.languageeng
dc.relationinfo:eu-repo/semantics/datasetDOI/https://doi.org/10.1371/journal.pone.0254025
dc.relationcitation:Martinez-Liu L, Hernandez-Guerrero R, Rivera-Gomez N, Martinez-Nuñez MA, Escobar-Turriza P, Peeters E, et al. (2021) Comparative genomics of DNA-binding transcription factors in archaeal and bacterial organisms. PLoS ONE 16(7): e0254025. https://doi.org/10.1371/journal.pone.0254025
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcePLoS ONE 16(7): e0254025. https://doi.org/10.1371/journal.pone.0254025
dc.subjectinfo:eu-repo/classification/Autores/ARCHAEA
dc.subjectinfo:eu-repo/classification/Autores/BACTERIA
dc.subjectinfo:eu-repo/classification/Autores/DNA, ARCHAEAL
dc.subjectinfo:eu-repo/classification/Autores/DNA, BACTERIAL
dc.subjectinfo:eu-repo/classification/Autores/GENOME SIZE
dc.subjectinfo:eu-repo/classification/Autores/GENOME, ARCHAEAL
dc.subjectinfo:eu-repo/classification/Autores/GENOME, BACTERIAL
dc.subjectinfo:eu-repo/classification/Autores/GENOMICS
dc.subjectinfo:eu-repo/classification/Autores/ISOELECTRIC POINT
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/24
dc.subjectinfo:eu-repo/classification/cti/2415
dc.subjectinfo:eu-repo/classification/cti/241502
dc.subjectinfo:eu-repo/classification/cti/241502
dc.titleComparative genomics of DNA-binding transcription factors in archaeal and bacterial organisms
dc.typeinfo:eu-repo/semantics/article


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