Biosynthesis of panaxynol and panaxydol in Panax ginseng

dc.creatorNihat Knispel
dc.creatorElena Ostrozhenkova
dc.creatorNicholas Schramek
dc.creatorClaudia Huber
dc.creatorLuis Manuel Peña Rodríguez
dc.creatorMercedes Bonfill
dc.creatorJavier Palazon
dc.creatorGesine Wischmann
dc.creatorRosa Maria Cusido
dc.creatorWolfgang Eisenreich
dc.date2013
dc.date.accessioned2023-07-21T19:18:47Z
dc.date.available2023-07-21T19:18:47Z
dc.identifierhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/1611
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7737171
dc.descriptionThe natural formation of the bioactive C17-polyacetylenes (−)-(R)-panaxynol and panaxydol was analyzed by 13C-labeling experiments. For this purpose, plants of Panax ginseng were supplied with 13CO2 under field conditions or, alternatively, sterile root cultures of P. ginseng were supplemented with [U-13C6]glucose. The polyynes were isolated from the labeled roots or hairy root cultures, respectively, and analyzed by quantitative NMR spectroscopy. The same mixtures of eight doubly 13C-labeled isotopologues and one single labeled isotopologue were observed in the C17-polyacetylenes obtained from the two experiments. The polyketide-type labeling pattern is in line with the biosynthetic origin of the compounds via decarboxylation of fatty acids, probably of crepenynic acid. The 13C-study now provides experimental evidence for the biosynthesis of panaxynol and related polyacetylenes in P. ginseng under in planta conditions as well as in root cultures. The data also show that 13CO2 experiments under field conditions are useful to elucidate the biosynthetic pathways of metabolites, including those from roots.
dc.formatapplication/pdf
dc.languageeng
dc.relationinfo:eu-repo/semantics/datasetDOI/10.3390/molecules18077686 
dc.relationcitation:Knispel, N., Ostrozhenkova, E., Schramek, N., Huber, C., Peña-Rodríguez, L., Bonfill, M., ... & Eisenreich, W. (2013). Biosynthesis of Panaxynol and Panaxydol in Panax ginseng. Molecules, 18(7), 7686-7698.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceMolecules, 18(7), 7686-7698, 2013
dc.subjectinfo:eu-repo/classification/Autores/PANAX GINSENG
dc.subjectinfo:eu-repo/classification/Autores/ARALIACEAE
dc.subjectinfo:eu-repo/classification/Autores/PANAXYNOL
dc.subjectinfo:eu-repo/classification/Autores/PANAXYDOL
dc.subjectinfo:eu-repo/classification/Autores/FALCARINOL
dc.subjectinfo:eu-repo/classification/Autores/POLYYNE
dc.subjectinfo:eu-repo/classification/Autores/CREPENYNIC ACID
dc.subjectinfo:eu-repo/classification/Autores/ISOTOPOLOGUE PROFILING
dc.subjectinfo:eu-repo/classification/Autores/13CO2
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/24
dc.subjectinfo:eu-repo/classification/cti/2407
dc.subjectinfo:eu-repo/classification/cti/240702
dc.subjectinfo:eu-repo/classification/cti/240702
dc.titleBiosynthesis of panaxynol and panaxydol in Panax ginseng
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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