New insights into the phylogeny of the TMBIM superfamily across the three of life: Comparative genomics and synteny networks reveal independent evolution of the BI and LFG families in plants

dc.creatorSAMUEL DAVID GAMBOA TUZ
dc.creatorALEJANDRO PEREIRA SANTANA
dc.creatorTao Zhao
dc.creatorM. Eric Schranz
dc.creatorEnrique Castaño de la Serna
dc.creatorLuis Carlos Rodríguez Zapata
dc.date2018
dc.date.accessioned2023-07-21T19:18:38Z
dc.date.available2023-07-21T19:18:38Z
dc.identifierhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/1544
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7737104
dc.descriptionThe Transmembrane BAX Inhibitor Motif containing (TMBIM) superfamily, divided into BAX Inhibitor (BI) and Lifeguard (LFG) families, comprises a group of cytoprotective cell death regulators conserved in prokaryotes and eukaryotes. However, no research has focused on the evolution of this superfamily in plants. We identified 685 TMBIM proteins in 171 organisms from Archaea, Bacteria, and Eukarya, and provided a phylogenetic overview of the whole TMBIM superfamily. Then, we used orthology and synteny network analyses to further investigate the evolution and expansion of the BI and LFG families in 48 plants from diverse taxa. Plant BI family forms a single monophyletic group; however, monocot BI sequences transposed to another genomic context during evolution. Plant LFG family, which expanded trough whole genome and tandem duplications, is subdivided in LFG I, LFG IIA, and LFG IIB major phylogenetic groups, and retains synteny in angiosperms. Moreover, two orthologous groups (OGs) are shared between bryophytes and seed plants. Other several lineage-specific OGs are present in plants. This work clarifies the phylogenetic classification of the TMBIM superfamily across the three domains of life. Furthermore, it sheds new light on the evolution of the BI and LFG families in plants providing a benchmark for future research.
dc.formatapplication/pdf
dc.languageeng
dc.relationinfo:eu-repo/semantics/datasetDOI/10.1016/j.ympev.2018.04.032
dc.relationcitation:Gamboa-Tuz, S. D., Pereira-Santana, A., Zhao, T., Schranz, M. E., Castano, E., & Rodriguez-Zapata, L. C. (2018). New insights into the phylogeny of the TMBIM superfamily across the three of life: Comparative genomics and synteny networks reveal independent evolution of the BI and LFG families in plants. Molecular phylogenetics and evolution, 126, 266-278.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceMolecular phylogenetics and evolution, 126, 266-278, 2018.
dc.subjectinfo:eu-repo/classification/Autores/BAX INHIBITOR 1
dc.subjectinfo:eu-repo/classification/Autores/GENE FAMILY EVOLUTION
dc.subjectinfo:eu-repo/classification/Autores/LIFEGUARD
dc.subjectinfo:eu-repo/classification/Autores/PROGRAMMED CELL DEATH
dc.subjectinfo:eu-repo/classification/Autores/SYNTENY NETWORK
dc.subjectinfo:eu-repo/classification/Autores/TMBIM
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/2
dc.titleNew insights into the phylogeny of the TMBIM superfamily across the three of life: Comparative genomics and synteny networks reveal independent evolution of the BI and LFG families in plants
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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