CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the ring domain that is present across eukaryotes

dc.creatorDOMINGO JIMENEZ LOPEZ
dc.creatorLAURA AGUILAR HENONIN
dc.creatorJUAN MANUEL GONZALEZ PRIETO
dc.creatorVíctor Hugo Aguilar Hernández
dc.creatorPLINIO ANTONIO GUZMAN VILLATE
dc.date2018
dc.date.accessioned2023-07-21T19:18:37Z
dc.date.available2023-07-21T19:18:37Z
dc.identifierhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/1528
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7737088
dc.descriptionRING ubiquitin E3 ligases enclose a RING domain for ubiquitin ligase activity and associated domains and/or conserved motifs outside the RING domain that collectively facilitate their classification and usually reveal some of key information related to mechanism of action. Here we describe a new family of E3 ligases that encodes a RING-H2 domain related in sequence to the ATL and BTL RING-H2 domains. This family, named CTL, encodes a motif designed as YEELL that expands 21 amino acids next to the RING-H2 domain that is present across most eukaryotic lineages. E3 ubiquitin ligase BIG BROTHER is a plant CTL that regulates organ size, and SUMO-targeted ubiquitin E3 ligase RNF111/ARKADIA is a vertebrate CTL. Basal animal and vertebrate, as well as fungi species, encode a single CTL gene that constraints the number of paralogs observed in vertebrates. Conversely, as previously described in ATL and BTL families in plants, CTL genes range from a single copy in green algae and 3 to 5 copies in basal species to 9 to 35 copies in angiosperms. Our analysis describes key structural features of a novel family of E3 ubiquitin ligases as an integral component of the set of core eukaryotic genes.
dc.formatapplication/pdf
dc.languageeng
dc.relationinfo:eu-repo/semantics/datasetDOI/10.1371/journal.pone.0190969
dc.relationcitation:Jiménez-López, D., Aguilar-Henonin, L., González-Prieto, J. M., Aguilar-Hernández, V., & Guzmán, P. (2018). CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the RING domain that is present across eukaryotes. PloS one, 13(1), e0190969.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcePloS one, 13(1), e0190969, 2018
dc.subjectinfo:eu-repo/classification/Autores/CTL PROTEIN
dc.subjectinfo:eu-repo/classification/Autores/PROTEIN
dc.subjectinfo:eu-repo/classification/Autores/UBIQUITIN PROTEIN LIGASE E3
dc.subjectinfo:eu-repo/classification/Autores/UNCLASSIFIED DRUG
dc.subjectinfo:eu-repo/classification/Autores/ZINC FINGER PROTEIN
dc.subjectinfo:eu-repo/classification/Autores/UBIQUITIN PROTEIN LIGASE
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/2
dc.titleCTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the ring domain that is present across eukaryotes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/submittedVersion


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