Fibrillarin from Archaea to human

dc.creatorULISES RODRIGUEZ CORONA
dc.creatorMARGARITA SOBOL
dc.creatorLUIS CARLOS RODRIGUEZ ZAPATA
dc.creatorPAVEL HOZAK
dc.creatorENRIQUE CASTAÑO DE LA SERNA
dc.date2015
dc.date.accessioned2023-07-21T19:17:45Z
dc.date.available2023-07-21T19:17:45Z
dc.identifierhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/1075
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7736645
dc.descriptionFibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.
dc.formatapplication/pdf
dc.languageeng
dc.relationinfo:eu-repo/semantics/datasetDOI/DOI: 10.1111/boc.201400077
dc.relationcitation:Rodriguez‐Corona, U., Sobol, M., Rodriguez‐Zapata, L. C., Hozak, P., & Castano, E. (2015). Fibrillarin from Archaea to human. Biology of the Cell, 107(6), 159-174.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceBiology of the Cell, 107(6), 159-174, 2015
dc.subjectinfo:eu-repo/classification/Autores/CANCER
dc.subjectinfo:eu-repo/classification/Autores/METHYLATION
dc.subjectinfo:eu-repo/classification/Autores/P53
dc.subjectinfo:eu-repo/classification/Autores/RIBOSOMAL BIOGÉNESIS
dc.subjectinfo:eu-repo/classification/Autores/RNA PROCESSING
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/2
dc.titleFibrillarin from Archaea to human
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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