Metabolite‐based genome‐wide association study enables dissection of the flavonoid decoration pathway of wheat kernels

dc.creatorChen, J.
dc.creatorXin Hu
dc.creatorTaotao Shi
dc.creatorHuanran Yin
dc.creatorDongfa Sun
dc.creatorYuanfeng Hao
dc.creatorXianchun Xia
dc.creatorJie Luo
dc.creatorFernie, A.R.
dc.creatorHe Zhonghu
dc.creatorWei Chen
dc.date2020-09-02T00:20:18Z
dc.date2020-09-02T00:20:18Z
dc.date2020
dc.date.accessioned2023-07-17T20:06:11Z
dc.date.available2023-07-17T20:06:11Z
dc.identifier1467-7652 (Print)
dc.identifierhttps://hdl.handle.net/10883/20943
dc.identifier10.1111/pbi.13335
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7512735
dc.descriptionThe marriage of metabolomic approaches with genetic design has proven a powerful tool in dissecting diversity in the metabolome and has additionally enhanced our understanding of complex traits. That said, such studies have rarely been carried out in wheat. In this study, we detected 805 metabolites from wheat kernels and profiled their relative contents among 182 wheat accessions, conducting a metabolite‐based genome‐wide association study (mGWAS) utilizing 14 646 previously described polymorphic SNP markers. A total of 1098 mGWAS associations were detected with large effects, within which 26 candidate genes were tentatively designated for 42 loci. Enzymatic assay of two candidates indicated they could catalyse glucosylation and subsequent malonylation of various flavonoids and thereby the major flavonoid decoration pathway of wheat kernel was dissected. Moreover, numerous high‐confidence genes associated with metabolite contents have been provided, as well as more subdivided metabolite networks which are yet to be explored within our data. These combined efforts presented the first step towards realizing metabolomics‐associated breeding of wheat.
dc.description1722-1735
dc.formatPDF
dc.languageEnglish
dc.publisherWiley Open Access
dc.publisherAssociation of Applied Biologists
dc.publisherSociety for Experimental Biology
dc.publisherBlackwell Publishing
dc.relationhttps://onlinelibrary.wiley.com/doi/full/10.1111/pbi.13335#support-information-section
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dc.rightsOpen Access
dc.source8
dc.source18
dc.sourcePlant Biotechnology Journal
dc.subjectFLAVONOIDS
dc.subjectMETABOLITES
dc.subjectWHEAT
dc.subjectKERNELS
dc.titleMetabolite‐based genome‐wide association study enables dissection of the flavonoid decoration pathway of wheat kernels
dc.typeArticle
dc.coverageOxford (United Kingdom)


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