| dc.creator | Villar-Hernandez, B.d.J. | |
| dc.creator | Perez-Elizalde, S. | |
| dc.creator | Crossa, J. | |
| dc.creator | Perez-Rodriguez, P. | |
| dc.creator | Toledo, F.H. | |
| dc.creator | Burgueño, J. | |
| dc.date | 2018-10-02T17:19:03Z | |
| dc.date | 2018-10-02T17:19:03Z | |
| dc.date | 2018 | |
| dc.date.accessioned | 2023-07-17T20:03:01Z | |
| dc.date.available | 2023-07-17T20:03:01Z | |
| dc.identifier | 2160-1836 | |
| dc.identifier | https://hdl.handle.net/10883/19624 | |
| dc.identifier | 10.1534/g3.118.200430 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7511508 | |
| dc.description | Plant and animal breeders are interested in selecting the best individuals from a candidate set for the next breeding cycle. In this paper, we propose a formal method under the Bayesian decision theory framework to tackle the selection problem based on genomic selection (GS) in single- and multi-trait settings. We proposed and tested three univariate loss functions (Kullback-Leibler, KL; Continuous Ranked Probability Score, CRPS; Linear-Linear loss, LinLin) and their corresponding multivariate generalizations (Kullback-Leibler, KL; Energy Score, EnergyS; and the Multivariate Asymmetric Loss Function, MALF). We derived and expressed all the loss functions in terms of heritability and tested them on a real wheat dataset for one cycle of selection and in a simulated selection program. The performance of each univariate loss function was compared with the standard method of selection (Std) that does not use loss functions. We compared the performance in terms of the selection response and the decrease in the population's genetic variance during recurrent breeding cycles. Results suggest that it is possible to obtain better performance in a long-term breeding program using the single-trait scheme by selecting 30% of the best individuals in each cycle but not by selecting 10% of the best individuals. For the multi-trait approach, results show that the population mean for all traits under consideration had positive gains, even though two of the traits were negatively correlated. The corresponding population variances were not statistically different from the different loss function during the 10th selection cycle. Using the loss function should be a useful criterion when selecting the candidates for selection for the next breeding cycle. | |
| dc.description | 3019-3037 | |
| dc.format | PDF | |
| dc.language | English | |
| dc.publisher | Genetics Society of America | |
| dc.relation | http://genomics.cimmyt.org/Decision_theory_GS/ | |
| dc.rights | CIMMYT manages Intellectual Assets as International Public Goods. The user is free to download, print, store and share this work. In case you want to translate or create any other derivative work and share or distribute such translation/derivative work, please contact CIMMYT-Knowledge-Center@cgiar.org indicating the work you want to use and the kind of use you intend; CIMMYT will contact you with the suitable license for that purpose. | |
| dc.rights | Open Access | |
| dc.source | 9 | |
| dc.source | 8 | |
| dc.source | G3: Genes, Genomes, Genetics | |
| dc.subject | AGRICULTURAL SCIENCES AND BIOTECHNOLOGY | |
| dc.subject | Bayesian Decision Theory | |
| dc.subject | Genomic Selection | |
| dc.subject | Loss Function | |
| dc.subject | Simulation Scenarios | |
| dc.subject | GenPred | |
| dc.subject | Shared Data Resources | |
| dc.subject | BAYESIAN THEORY | |
| dc.subject | GENOMICS | |
| dc.subject | SELECTION | |
| dc.subject | SIMULATION | |
| dc.title | A Bayesian decision theory approach for genomic selection | |
| dc.type | Article | |
| dc.coverage | Bethesda, Md., U.S. | |
