Genome-wide association study in Asia-adapted tropical maize reveals novel and explored genomic regions for sorghum downy mildew resistance

dc.creatorRashid, Z.
dc.creatorKumar Singh, P.
dc.creatorVemuri, H.
dc.creatorZaidi, P.H.
dc.creatorPrasanna, B.M.
dc.creatorNair, S.K.
dc.date2018-01-24T20:01:52Z
dc.date2018-01-24T20:01:52Z
dc.date2017
dc.date.accessioned2023-07-17T20:02:01Z
dc.date.available2023-07-17T20:02:01Z
dc.identifierhttp://hdl.handle.net/10883/19185
dc.identifier10.1038/s41598-017-18690-3
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7511100
dc.descriptionGlobally, downy mildews are among the important foliar diseases of maize that cause significant yield losses. We conducted a genome-wide association study for sorghum downy mildew (SDM; Peronosclerospora sorghi) resistance in a panel of 368 inbred lines adapted to the Asian tropics. High density SNPs from Genotyping-by-sequencing were used in GWAS after controlling for population structure and kinship in the panel using a single locus mixed model. The study identified a set of 26 SNPs that were significantly associated with SDM resistance, with Bonferroni corrected P values ≤ 0.05. Among all the identified SNPs, the minor alleles were found to be favorable to SDM resistance in the mapping panel. Trend regression analysis with 16 independent genetic variants including 12 SNPs and four haplotype blocks identified SNP S2_6154311 on chromosome 2 with P value 2.61E-24 and contributing 26.7% of the phenotypic variation. Six of the SNPs/haplotypes were within the same chromosomal bins as the QTLs for SDM resistance mapped in previous studies. Apart from this, eight novel genomic regions for SDM resistance were identified in this study; they need further validation before being applied in the breeding pipeline. Ten SNPs identified in this study were co-located in reported mildew resistance genes.
dc.formatPDF
dc.languageEnglish
dc.publisherNature Publishing Group
dc.relationMaize
dc.relationhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41598-017-18690-3/MediaObjects/41598_2017_18690_MOESM1_ESM.doc
dc.relationhttp://hdl.handle.net/11529/10201
dc.rightsCIMMYT manages Intellectual Assets as International Public Goods. The user is free to download, print, store and share this work. In case you want to translate or create any other derivative work and share or distribute such translation/derivative work, please contact CIMMYT-Knowledge-Center@cgiar.org indicating the work you want to use and the kind of use you intend; CIMMYT will contact you with the suitable license for that purpose.
dc.rightsOpen Access
dc.sourceart. 366
dc.source8
dc.sourceScientific Reports
dc.subjectAGRICULTURAL SCIENCES AND BIOTECHNOLOGY
dc.subjectMAIZE
dc.subjectGENOMES
dc.subjectSINGLE NUCLEOTIDE POLYMORPHISM
dc.subjectTROPICAL ZONES
dc.subjectDISEASE RESISTANCE
dc.titleGenome-wide association study in Asia-adapted tropical maize reveals novel and explored genomic regions for sorghum downy mildew resistance
dc.typeArticle
dc.coverageSAHARAN AFRICA
dc.coverageSOUTH ASIA
dc.coverageSOUTHEAST ASIA
dc.coverageLATIN AMERICA
dc.coverageLondon


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