| dc.creator | Islan, Germán Abel | |
| dc.creator | Bosio, Valeria Elizabeth | |
| dc.creator | Castro, Guillermo Raúl | |
| dc.date | 2013 | |
| dc.date | 2023-05-18T17:06:21Z | |
| dc.date.accessioned | 2023-07-15T10:35:12Z | |
| dc.date.available | 2023-07-15T10:35:12Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/153221 | |
| dc.identifier | issn:1616-5195 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7492428 | |
| dc.description | A new formulation is described based on biopolymeric microspheres containing alginate lyase (AL) and ciprofloxacin (Cip) for sustainable oral delivery in CF patients. Alginate (ALG) and high-methoxyl pectin (HMP) are selected as the biopolymers to develop a composite matrix.
ALG microspheres coated with HMP and ALG-HMP blend are gelled in water/organic solvents mixtures, obtaining Cip encapsulations from 46.0 to 100.0%. ALG-HMP shows a Cip sustainable release profile and is able to encapsulate 90.0% of AL, showing 76.0% enzyme activity after release under simulated intestinal conditions. The developed system is a promising delivery carrier to treat chronic infection of Pseudomonas aeruginosa and to reduce the viscoelasticity of the mucus accumulated into intestine of CF patients. | |
| dc.description | Centro de Investigación y Desarrollo en Fermentaciones Industriales | |
| dc.format | application/pdf | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
| dc.subject | Biología | |
| dc.subject | alginate lyase | |
| dc.subject | Biopolymers | |
| dc.subject | Ciprofloxacin | |
| dc.subject | Cystic fibrosis | |
| dc.subject | Drug delivery | |
| dc.title | Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment | |
| dc.type | Articulo | |
| dc.type | Articulo | |
