Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays

dc.creatorSuárez, Santiago Emmanuel
dc.creatorAphalo, Paula
dc.creatorRinaldi, Gustavo
dc.creatorAñón, María Cristina
dc.creatorQuiroga, Alejandra Viviana
dc.date2020
dc.date2023-04-13T18:14:59Z
dc.date.accessioned2023-07-15T10:09:42Z
dc.date.available2023-07-15T10:09:42Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/151446
dc.identifierissn:0308-8146
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7490815
dc.descriptionThe aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an O:W emulsion on the integrity of the antihypertensive peptides. All samples tested produced a decrease in blood pressure (SBP). The animals treated with emulsion (GE) and emulsion+peptide (GE+VIKP) showed the most significant reduction in the SBP (42 ± 2 mmHg and 35 ± 2 mmHg, respectively). The results presented suggest that after GID, a variety of peptides with biological activities were released or were resistant to this process. These peptides play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular system. These results support the use of amaranth protein/peptides in the elaboration of functional foods for hypertensive individuals.
dc.descriptionCentro de Investigación y Desarrollo en Criotecnología de Alimentos
dc.descriptionFacultad de Ciencias Médicas
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)
dc.subjectCiencias Exactas
dc.subjectAmaranth proteins
dc.subjectAntihypertensive activity
dc.subjectProtein hydrolysate
dc.subjectSpontaneously hypertensive rats
dc.subjectRenin-angiotensin system
dc.titleEffect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
dc.typeArticulo
dc.typeArticulo


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